Gene families: The taxonomy of protein paralogs and chimeras
Gene families: The taxonomy of protein paralogs and chimeras
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DOI：
10.1126/science.278.5338.609
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发表时间：
1997-10-24
期刊：
影响因子：
56.9
通讯作者：
Hood, L
中科院分区：
文献类型：
--
作者：
Henikoff, S;Greene, EA;Hood, L
古老的蛋白质编码片段的复制和重排导致了复杂的基因家族关系。复制可以是串联的或分散的，并且可以涉及与折叠的蛋白质结构域相对应的整个编码区或模块。因此，基因产品可能会获得新的特异性、改变的识别特性或修改的功能。有机体中某些家族的极端增殖，可能是以牺牲其他家族为代价的，可能与进化过程中的功能创新相对应。潜在的过程仍然在发挥作用，人类和其他基因组中的很大一部分由转座元件组成，这可能是基因组灵活性进化益处的一种表现。
Ancient duplications and rearrangements of protein-coding segments have resulted in complex gene family relationships. Duplications can be tandem or dispersed and can involve entire coding regions or modules that correspond to folded protein domains. As a result, gene products may acquire new specificities, altered recognition properties, or modified functions. Extreme proliferation of some families within an organism, perhaps at the expense of other families, may correspond to functional innovations during evolution. The underlying processes are still at work, and the large fraction of human and other genomes consisting of transposable elements may be a manifestation of the evolutionary benefits of genomic flexibility.