Ifenprodil tartrate treatment of adolescents with post-traumatic stress disorder: A double-blind, placebo-controlled trial
Ifenprodil tartrate treatment of adolescents with post-traumatic stress disorder: A double-blind, placebo-controlled trial
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酒石酸艾芬地尔治疗患有创伤后应激障碍的青少年：一项双盲、安慰剂对照试验
DOI：
10.1016/j.psychres.2022.114486
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发表时间：
2022
影响因子：
11.3
通讯作者：
Iyo Masaomi
中科院分区：
文献类型：
--
作者：
Sasaki Tsuyoshi;Hashimoto Kenji;Niitsu Tomihisa;Hosoda Yutaka;Oda Yasunori;Shiko Yuki;Ozawa Yoshihito;Kawasaki Yohei;Kanahara Nobuhisa;Shiina Akihiro;Hashimoto Tasuku;Suzuki Takaaki;Sugawara Takeshi;Hanaoka Hideki;Iyo Masaomi
背景许多证据表明，通过N-甲基-D-天冬氨酸（NMDA）受体的谷氨酸能神经传递在创伤后应激障碍（PTSD）的某些常见行为表现中起作用。酒石酸艾芬地尔是一种神经保护剂，与NMDA受体的GluN 2B亚基结合。本研究的目的是确认酒石酸艾芬地尔是否对青少年PTSDpatients.MethodsThis是一项随机、双盲、安慰剂对照试验。10例青少年（13 ~ 18岁）PTSD患者随机分为两组：安慰剂组（n= 4）和酒石酸艾芬地尔组（n= 6），治疗4周。所有患者均采用IES-R-J（Primary outcome measure）、TSCC-J、CDRS-R、DSRS-C-J和CGI-I进行评估。结果基线IES-R-J总分与4周终点评分比较显示轻度改善趋势（p= 0.0895），差异评分为-9.314。基线评分和2周中间点评分的比较显示，IES-R-J过度唤醒子评分和TSCC-J子评分（分离子评分，性问题子评分）显著改善。比较基线TSCC-J性关注subscores和4周的终点分数显着improved.ConclusionsOur研究可能被证明是一个短期有效的替代安全治疗青少年PTSD患者。
BackgroundSeveral lines of evidence suggest that glutamatergic neurotransmission via the N-methyl-D-aspartate (NMDA) receptor plays a role in certain behavioral manifestations common to Post-Traumatic Stress Disorder (PTSD). Ifenprodil tartrate is a neuroprotective agent that binds to the GluN2B subunit of the NMDA receptor. The aim of this study is to confirm whether ifenprodil tartrate is effective in the adolescent PTSD patients.MethodsThis is a randomized, double-blind, placebo‐controlled trial. Ten adolescent (13 to 18 years old) PTSD patients were randomized into two arms: placebo (n= 4), 40 mg/day ifenprodil tartrate (n= 6) for 4 weeks. All of the patients were assessed by IES-R-J (Primary outcome measure), TSCC-J, CDRS-R, DSRS-C-J and CGI-I.ResultsA comparison of baseline IES-R-J total scores and 4-week end-point scores showed a mild trend of improvement (p= 0.0895) and the difference score was -9.314. A comparison of baseline scores and 2-week intermediate-point scores showed that IES-R-J hyperarousal subscores and TSCC-J subscores (dissociation subscores, sexual concerns subscores) improved significantly. A comparison of baseline TSCC-J sexual concerns subscores and 4-week end-point scores improved significantly.ConclusionsOur study may prove to be an short-term effective alternative safe treatment for adolescent patients with PTSD.