Association of extent and aggressiveness of inflammation with serum PSA levels and PSA density in asymptomatic patients
Association of extent and aggressiveness of inflammation with serum PSA levels and PSA density in asymptomatic patients
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DOI：
10.1016/j.urology.2007.06.1102
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发表时间：
2007-10-01
期刊：
影响因子：
2.1
通讯作者：
Metin, Ahmet
中科院分区：
文献类型：
--
作者：
Kandirali, Eagin;Boran, Cetin;Metin, Ahmet
血清前列腺特异性抗原（PSA）水平与组织学前列腺炎症之间的关系存在争议。以前的研究使用炎症的强度或程度进行分级，样本数量相对较少。在我们的研究中，炎症进行了更深入的分类，使用炎症的强度和程度，以确定前列腺炎症对血清PSA水平，游离PSA百分比（%fPSA）和PSA密度（PSAD）的影响。为了对炎症进行分类，使用了包括炎症强度和程度的分级方法。分析炎症的程度和侵袭性。患者被分为五个等级的程度和四个等级的侵略性炎症组。结果炎症程度与血清PSA水平呈正相关（r = 0.423，P < 0.01），炎症程度与血清PSA水平呈正相关（r = 0.423，P < 0.01），炎症程度与血清PSA水平呈正相关（r = 0.423，P < 0.01）。
OBJECTIVES The relationship between serum prostate-specific antigen (PSA) levels and histologic prostatic inflammation is controversial. Previous studies were performed using either the intensity or extent of inflammation for grading, with a relatively lower number of specimens. In our study, the inflammation was categorized more profoundly, using both the intensity and the extent of inflammation, to determine the influence of prostatic inflammation on serum PSA levels, percent free PSA (%fPSA), and PSA density (PSAD).METHODS The study included 115 patients who underwent transrectal ultrasound-guided prostate biopsy. To categorize the inflammation, a grading method that included the intensity and extent of inflammation was used. The extent and aggressiveness of inflammation were analyzed. The patients were divided into groups using five grades for the extent and four grades for the aggressiveness of inflammation. The serum PSA Levels, fPSA levels, %fPSA, and PSAD in each group were compared.RESULTS The extent of inflammation grade correlated positively with the serum PSA level (r = 0.423, P