Human fetuses are able to mount an adultlike CD8 T-cell response
Human fetuses are able to mount an adultlike CD8 T-cell response
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DOI：
10.1182/blood.v100.6.2153.h81802002153_2153_2158
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发表时间：
2002-09-15
期刊：
影响因子：
20.3
通讯作者：
Carlier, Y
中科院分区：
文献类型：
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作者：
Hermann, E;Truyens, C;Carlier, Y
胎儿/新生儿的免疫反应通常被认为不成熟且比成人弱。我们研究了先天性感染克氏锥虫（恰加斯病的原生动物）的新生儿的脐带血 T 细胞。我们的数据表明 CD8 T 细胞表达激活标记物并介导效应功能的主要激活。 T 细胞受体 β 链可变组库的分析显示这些 T 淋巴细胞的寡克隆扩增，表明激活是由寄生虫抗原驱动的。事实上，我们已经检测到寄生虫特异性 CD8 T 细胞在与活克氏锥虫共孵育后分泌干扰素-γ。这种反应在重组 interieukin-15 的存在下增强，从而限制了 T 细胞自发凋亡。这些发现指出，胎儿的免疫系统比以前认为的更强大，因为暴露于活病原体的胎儿能够产生类似成人的免疫 CD8 T 细胞反应。
Fetal/neonatal immune responses generally are considered to be immature and weaker than that of adults. We have studied the cord-blood T cells of newborns congenitally infected with Trypanosoma cruzi, the protozoan agent of Chagas disease. Our data demonstrate a predominant activation of CD8 T cells expressing activation markers and armed to mediate effector functions. The analysis of the T-cell receptor beta chain variable repertoire shows the oligoclonal expansion of these T lymphocytes, indicating that activation was driven by parasite antigens. Indeed, we have detected parasite-specific CD8 T cells secreting interferon-gamma after coincubation with live T cruzi. This response is enhanced in the presence of recombinant interieukin-15, which limits the T-cell spontaneous apoptosis. These findings point out that the fetal immune system is more competent than previously appreciated, since fetuses exposed to live pathogens are able to develop an adultlike immune CD8 T-cell response.