Marital status and survival in patients with primary liver cancer.
Marital status and survival in patients with primary liver cancer.
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原发性肝癌患者的婚姻状况和生存率。
DOI：
10.18632/oncotarget.11066
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发表时间：
2017-09-12
期刊：
影响因子：
--
通讯作者：
Sun LM
中科院分区：
文献类型：
--
作者：
He XK;Lin ZH;Qian Y;Xia D;Jin P;Sun LM
婚姻状况被认为是影响各种癌症患者生存的独立预后因素。然而，其在原发性肝癌中的作用尚未得到充分的探讨。目的探讨婚姻状况对肝癌患者生存结局的影响。2004年至2012年间，我们最终确定了40,809例符合条件的肝癌患者，其中21,939例（53.8%）患者在诊断时已婚，18,870例（46.2%）患者未婚（包括5871例离婚/分居，4,338例丧偶和8,660例单身）。与离婚/分居、丧偶和单身的患者相比，已婚患者享有总体和特定原因的生存结果。即使在调整了已知的混杂因素后，与婚姻相关的生存优势仍然存在。与其他群体相比，丧偶的个体总体上和癌症特异性死亡的风险更高。在根据SEER分期进行的亚组分析中也观察到类似的关联。我们使用监测、流行病学和最终结果（SEER）数据库来确定2004年至2012年间诊断为原发性肝癌的40,809例患者。采用Kaplan-Meier分析和Cox回归分析确定婚姻状况对总生存期（OS）和肝癌特异性生存期（CSS）的影响。在原发性肝癌患者中，无论是总体生存期还是肿瘤特异性生存期，已婚患者都享有生存优势，而丧偶患者则处于生存劣势。
Marital status is viewed as an independent prognostic factor for survival in various cancer types. However, its role in primary liver cancer has yet to be thoroughly explored. To investigate the impact of marital status on survival outcomes among liver cancer patients. We finally identified 40,809 eligible liver cancer patients between 2004 and 2012, including 21,939 (53.8%) patients were married at diagnosis and 18,870 (46.2%) were unmarried (including 5,871 divorced/separated, 4,338 widowed and 8,660 single). Married patients enjoyed overall and cause-specific survival outcomes compared with patients who were divorced/separated, widowed, single, respectively. The survival benefit associated with marriage still persisted even after adjusted for known confounders. Widowed individuals were at greater risk of overall and cancer-specific mortality compared to other groups. Similar associations were observed in subgroup analyses according to SEER stage. We used the Surveillance, Epidemiology and End Results (SEER) database to identify 40,809 patients diagnosed with primary liver cancer between 2004 and 2012. Kaplan-Meier analysis and Cox regression were performed to identify the influence of marital status on overall survival (OS) and liver cancer-specific survival (CSS). In primary liver cancer patients, married patients enjoyed survival benefits while widowed persons suffered survival disadvantages in both overall survival and cancer-specific survival.
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影响因子：
3.7
作者：
Ljung R;Drefahl S;Andersson G;Lagergren J
通讯作者：
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DOI：
10.1161/circinterventions.112.968271
发表时间：
2012-10-01
影响因子：
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发表时间：
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影响因子：
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作者：
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