Normative Development of White Matter Tracts: Similarities and Differences in Relation to Age, Gender, and Intelligence
Normative Development of White Matter Tracts: Similarities and Differences in Relation to Age, Gender, and Intelligence
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DOI：
10.1093/cercor/bhr243
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发表时间：
2012-08-01
期刊：
影响因子：
3.7
通讯作者：
Vargha-Khadem, Faraneh
中科院分区：
文献类型：
--
作者：
Clayden, Jonathan D.;Jentschke, Sebastian;Vargha-Khadem, Faraneh
大脑的白色物质在整个发育过程中经历了一系列的结构变化;从怀孕到出生，在婴儿期，并通过儿童和青少年向前发展。几项研究已经使用扩散磁共振成像（dMRI）来研究这些变化，但尚未达成共识的白色物质束在发展的后期阶段发生变化或这些变化背后最重要的驱动因素是什么。在这项针对8至16岁儿童的研究中，我们使用基于主成分分析的综合数据驱动方法来确定年龄，性别和脑容量对dMRI参数的影响，以及它们的相对重要性。我们还表明，这些参数的次要成分预测全面的智商，独立的年龄和性别相关的影响。这种总体评估的共同因素和性别差异，在正常的白色物质道的发展将有助于促进这一进程的理解，在儿童后期和青春期。
The white matter of the brain undergoes a range of structural changes throughout development; from conception to birth, in infancy, and onwards through childhood and adolescence. Several studies have used diffusion magnetic resonance imaging (dMRI) to investigate these changes, but a consensus has not yet emerged on which white matter tracts undergo changes in the later stages of development or what the most important driving factors are behind these changes. In this study of typically developing 8- to 16-year-old children, we use a comprehensive data-driven approach based on principal components analysis to identify effects of age, gender, and brain volume on dMRI parameters, as well as their relative importance. We also show that secondary components of these parameters predict full-scale IQ, independently of the age- and gender-related effects. This overarching assessment of the common factors and gender differences in normal white matter tract development will help to advance understanding of this process in late childhood and adolescence.