Volume cerebral blood flow reduction in pre-clinical stage of Alzheimer disease: Evidence from an ultrasonographic study
Volume cerebral blood flow reduction in pre-clinical stage of Alzheimer disease: Evidence from an ultrasonographic study
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DOI：
10.1007/s00415-005-0689-z
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发表时间：
2005-05-01
影响因子：
6
通讯作者：
Padovani, A
中科院分区：
文献类型：
--
作者：
Akkawi, NM;Borroni, B;Padovani, A
脑血流量减少与阿尔茨海默病（AD）的发展之间的关系已成为最近关注的目标。通过使用神经影像学技术，越来越多的注意力已经致力于识别临床前AD。在这项研究中，彩色多普勒超声颈部动脉测量平均脑血流量（CBF）的55名遗忘型轻度认知功能障碍（MCI）患者。入组后2年，排除进展为AD以外痴呆的患者，确定了两个亚组，即发展为AD的患者（MCI转换者）和认知和功能水平保持不变的患者（MCI非转换者）。检查获得的两个亚组中基线测量的CBF的平均差异，注意到显著差异（MCI转换者539.3 +/- 114.3 vs MCI非转换者636.0 +/- 143.9，p < 0.05）。CBF高于中位数（558 ml/min）的MCI患者在2年随访内发生AD的风险较低（特异性72.2%，敏感性68.4%）。颈部动脉超声检查是一种简单、无创和广泛应用的技术，可用于检测MCI阶段的CBF下降，从而识别以后将转化为AD的患者。
The association of decreased cerebral blood flow with the development of Alzheimer's disease (AD) has been a recent target of interest. By using neuroimaging techniques, growing attention has been devoted to the identification of preclinical AD.In this study, color duplex sonography of cervical arteries was used to measure mean cerebral blood flow (CBF) on 55 amnestic Mild Cognitive Impairment (MCI) patients. Two years after enrolment, excluding patients who progressed to dementia other than AD, two subgroups were identified, patients who developed AD (MCI converters) and patients with preserved cognitive and functional level (MCI non- converters). Examining the mean difference of CBF measured at baseline in the two subgroups obtained, a significant difference was noticed (MCI converters 539.3 +/- 114.3 vs MCI non converters 636.0 +/- 143.9, p < 0.05). MCI patients with CBF higher than median value (558 ml/min) had lower risk of developing AD (specificity 72.2 %, sensitivity 68.4 %) within a two year follow-up. Ultrasonography of the cervical arteries is a simple, non invasive and widespread technique useful in detecting CBF decline during the MCI stage, thus identifying patients who later will convert to AD.