Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks
Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks
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DOI：
10.1038/nn1571
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发表时间：
2005-11-01
影响因子：
25
通讯作者：
Heinemann, U
中科院分区：
文献类型：
--
作者：
Behrens, CJ;van den Boom, LP;Heinemann, U
海马尖波纹波复合体（SPW-Rs）发生在慢波睡眠和行为不动期间，被认为代表了记忆巩固期间转移到新皮层的存储信息。本研究表明，刺激诱发长期增强（LTP）（一种与学习和记忆相关的神经生理）可以导致大鼠海马切片产生SPW-Rs。诱导的SPW-Rs具有与自发产生的SPW-Rs相同的特性：它们起源于CA3，传播到CA1和下骨，并需要AMPA/盐酸盐受体。它们的诱导依赖于NMDA受体，并涉及CA3网络中神经元簇之间相互作用的变化。它们的表达可被低频刺激阻断，而非NMDA受体拮抗剂。这些数据表明，在循环CA3网络中LTP的诱导可能促进SPW-Rs的产生。
Hippocampal sharp wave-ripple complexes (SPW-Rs) occur during slow-wave sleep and behavioral immobility and are thought to represent stored information that is transferred to the neocortex during memory consolidation. Here we show that stimuli that induce long-term potentiation (LTP), a neurophysiological correlate of learning and memory, can lead to the generation of SPW-Rs in rat hippocampal slices. The induced SPW-Rs have properties that are identical to spontaneously generated SPW-Rs: they originate in CA3, propagate to CA1 and subiculum and require AMPA/kainate receptors. Their induction is dependent on NMDA receptors and involves changes in interactions between clusters of neurons in the CA3 network. Their expression is blocked by low-frequency stimulation but not by NMDA receptor antagonists. These data indicate that induction of LTP in the recurrent CA3 network may facilitate the generation of SPW-Rs.