The NOD Mouse Beyond Autoimmune Diabetes.
The NOD Mouse Beyond Autoimmune Diabetes.
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DOI：
10.3389/fimmu.2022.874769
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发表时间：
2022
影响因子：
7.3
通讯作者：
Lesage, Sylvie
中科院分区：
文献类型：
--
作者：
Aubin, Anne-Marie;Lombard-Vadnais, Felix;Collin, Roxanne;Aliesky, Holly A.;McLachlan, Sandra M.;Lesage, Sylvie
自身免疫性糖尿病在非肥胖糖尿病（NOD）小鼠中自发发生，并且这种疾病的病理生理学与人类1型糖尿病有许多相似之处。自1980年诞生以来，源自Cataract Shinogi品系的NOD小鼠一直代表着自发性疾病模型的黄金标准，可以研究自身免疫性糖尿病疾病的进展和易感性特征，并测试各种潜在的治疗方法和疗法。除了自身免疫性糖尿病，NOD小鼠还表现出多种自身免疫性，表现出自身免疫性甲状腺炎和舍格伦综合征的低发病率。NOD菌株的遗传操作导致了新小鼠模型的产生，促进了这些和其他自身免疫性病理学的研究。例如，在删除特定基因或通过在遗传基因座插入抗性等位基因后，NOD小鼠可以对自身免疫性糖尿病具有完全抗性;然而，新产生的糖尿病抗性NOD菌株通常显示出其他自身免疫性疾病的高发病率。这表明NOD的遗传背景是高度自身免疫倾向的，并且遗传操作可以将自身免疫反应从胰腺转移到其他器官。总体而言，多种NOD变异株已成为了解器官特异性自身免疫性疾病的病理生理学和解剖器官特异性自身免疫性疾病的遗传易感性的宝贵工具。在NOD小鼠的变体品系中发展的所有自身免疫性疾病的一个有趣的共性是自身抗体的存在。这篇综述将NOD小鼠作为研究自身免疫性糖尿病以外的自身免疫性疾病的模型。
Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1 diabetes. Since its generation in 1980, the NOD mouse, derived from the Cataract Shinogi strain, has represented the gold standard of spontaneous disease models, allowing to investigate autoimmune diabetes disease progression and susceptibility traits, as well as to test a wide array of potential treatments and therapies. Beyond autoimmune diabetes, NOD mice also exhibit polyautoimmunity, presenting with a low incidence of autoimmune thyroiditis and Sjögren’s syndrome. Genetic manipulation of the NOD strain has led to the generation of new mouse models facilitating the study of these and other autoimmune pathologies. For instance, following deletion of specific genes or via insertion of resistance alleles at genetic loci, NOD mice can become fully resistant to autoimmune diabetes; yet the newly generated diabetes-resistant NOD strains often show a high incidence of other autoimmune diseases. This suggests that the NOD genetic background is highly autoimmune-prone and that genetic manipulations can shift the autoimmune response from the pancreas to other organs. Overall, multiple NOD variant strains have become invaluable tools for understanding the pathophysiology of and for dissecting the genetic susceptibility of organ-specific autoimmune diseases. An interesting commonality to all autoimmune diseases developing in variant strains of the NOD mice is the presence of autoantibodies. This review will present the NOD mouse as a model for studying autoimmune diseases beyond autoimmune diabetes.
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影响因子：
5
作者：
通讯作者：
--
影响因子：
7.7
作者：
BERNARD, NF;ERTUG, F;MARGOLESE, H
通讯作者：
MARGOLESE, H
影响因子：
56.9
作者：
Anderson, MS;Venanzi, ES;Mathis, D
通讯作者：
Mathis, D
影响因子：
3.7
作者：
BAXTER, AG;HEALEY, D;COOKE, A
通讯作者：
COOKE, A
DOI：
10.1084/jem.20022125
发表时间：
2003-07-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ansari MJ;Salama AD;Chitnis T;Smith RN;Yagita H;Akiba H;Yamazaki T;Azuma M;Iwai H;Khoury SJ;Auchincloss H Jr;Sayegh MH
通讯作者：
Sayegh MH