Association of individual and community factors with C-reactive protein and 25-hydroxyvitamin D: Evidence from the National Health and Nutrition Examination Survey (NHANES).
Association of individual and community factors with C-reactive protein and 25-hydroxyvitamin D: Evidence from the National Health and Nutrition Examination Survey (NHANES).
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DOI：
10.1016/j.ssmph.2016.11.001
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Wen M
中科院分区：
文献类型：
--
作者：
Chai W;Fan JX;Wen M
许多个人和社区/邻里因素可能会导致炎症和维生素 D 缺乏，从而导致慢性疾病的发展。本研究使用 2001-2006 年国家健康和营养检查调查 (NHANES) 的全国代表性样本，研究了血清 C 反应蛋白 (CRP) 和 25-羟基维生素 D [25(OH)D] 水平与个人和社区/邻里（地区级或县级）因素的关联。 2001-2006 年连续 NHANES 波次的数据与 2000 年人口普查和使用地理信息系统构建的其他邻里数据源合并。使用多水平随机截距回归模型评估多水平因素和生物标志物水平之间的关联。 6643 名 19-65 岁的参与者（3402 名男性和 3241 名女性）参与了分析。家庭收入需求比与 CRP 呈负相关（P=0.002），与 25(OH)D 水平呈正相关（P=0.0003）。县犯罪率与 CRP 呈正相关 (P=0.007)，与 25(OH)D 水平呈负相关 (P=0.0002)。男性中收入与需求比的相关性显着[CRP，P=0.005； 25(OH)D，P=0.005]但女性中没有。对于县犯罪率，CRP 的相关性仅在女性中显着 (P=0.004)，而 25(OH)D 的相关性在男性 (P=0.01) 和女性 (P=0.001) 中均显着。此外，总体 CRP 与年龄 (P<0.0001)、女性 (P<0.0001)、西班牙裔人种/民族 (P=0.0001)、当前吸烟者 (P<0.0001)、体重指数 (BMI，P<0.0001) 和美国出生的参与者 (P=0.02) 呈正相关。非西班牙裔黑人 (P<0.0001) 和西班牙裔人种/民族 (P<0.0001)、当前吸烟者 (P=0.047) 和较高的 BMI (P<0.0001) 与较低的血清 25(OH)D 水平相关。其他社区/邻里变量与血清 CRP 和 25(OH)D 水平之间没有观察到显着关联。目前的结果表明，家庭收入与需求的比率和县犯罪率可能是慢性炎症和维生素 D 状况的重要影响因素。 CRP 与家庭收入需求比呈显着负相关。 CRP 与县犯罪率呈显着正相关。 25-羟基维生素 D 与家庭收入需求比呈显着正相关。 25-羟基维生素 D 与县犯罪率呈显着负相关。家庭收入与需求之比和县犯罪率可能是导致慢性炎症和维生素缺乏的重要因素。
Many individual and community/neighborhood factors may contribute to inflammation and vitamin D deficiency leading to the development of chronic diseases. This study examined the associations of serum C-reactive protein (CRP) and 25-hydroxyvitamin D [25(OH)D] levels with individual and community/neighborhood (tract-level or county-level) factors using a nationally representative sample from 2001–2006 National Health and Nutrition Examination Survey (NHANES). Data from the 2001–2006 waves of the continuous NHANES was merged with the 2000 census and other neighborhood data sources constructed using geographic information system. Associations between multilevel factors and biomarker levels were assessed using multilevel random-intercept regression models. 6643 participants aged 19–65 (3402 men and 3241 women) were included in the analysis. Family income-to-needs ratio was inversely associated with CRP (P=0.002) and positively associated with 25(OH)D levels (P=0.0003). County crime rates were positively associated with CRP (P=0.007) and inversely associated with 25(OH)D levels (P=0.0002). The associations with income-to-needs ratio were significant in men [CRP, P=0.005; 25(OH)D, P=0.005] but not in women. For county crime rates, the association was only significant in women for CRP (P=0.004) and was significant in both men (P=0.01) and women (P=0.001) for 25(OH)D. Additionally, overall CRP was positively associated with age (P<0.0001), female sex (P<0.0001), Hispanic race/ethnicity (P=0.0001), current smokers (P<0.0001), body mass index (BMI, P<0.0001), and participants who were US-born (P=0.02). Non-Hispanic black (P<0.0001) and Hispanic race/ethnicity (P<0.0001), current smoker (P=0.047), and higher BMI (P<0.0001) were associated with lower serum 25(OH)D levels. No significant associations were observed between other community/neighborhood variables and serum CRP and 25(OH)D levels. The current results suggest that family income-to-needs ratio and county crime rate may be important contributors to chronic inflammation and vitamin D status. Significantly inverse association of CRP with family income-to-needs ratio. Significantly positive association of CRP with county crime rates. Significantly positive association of 25-hydroxyvitamin D with family income-to-needs ratio. Significantly inverse association of 25-hydroxyvitamin D with county crime rates. Family income-to-needs ratio and county crime rate may be important factors contributing to chronic inflammation and vitamin deficiency.