Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
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DOI：
10.1016/j.neuro.2008.06.001
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发表时间：
2008-09-01
期刊：
影响因子：
3.4
通讯作者：
Clarkson, Thomas W.
中科院分区：
文献类型：
--
作者：
Davidson, Philip W.;Strain, J. J.;Clarkson, Thomas W.
鱼类含有促进大脑最佳生长和发育的营养素，但也含有可能具有毒性作用的甲基汞（MeHg）。本研究检验了这一假设，即在估计产前甲基汞暴露对儿童发育的影响时，鱼类中选定营养素的摄入量或母体营养状况的测量可能是重要的混杂因素。这项研究在塞舌尔共和国进行，塞舌尔是一个印度洋群岛，鱼类消费量很高。采用纵向队列研究设计。共有300名母亲在怀孕早期登记。在怀孕沿着测量了被认为对大脑发育很重要的营养素以及产前接触甲基汞的情况。这些孩子定期接受评估，直到30个月大。共有229名儿童有完整的结局和协变量数据进行分析。主要终点是9个月和30个月时使用的Bayley婴儿发育量表-II（BSID-II）。在5、9和25个月时，还提供了婴儿认知和记忆的四个次级测量的组合。队列母亲每周平均食用537克鱼（9餐含鱼）。母亲头发中的平均产前甲基汞暴露量为5.9 ppm。初步分析研究了甲基汞、母亲营养措施和儿童BSID-II评分之间的关联，结果显示，甲基汞与30个月时的平均精神发育指数评分之间存在不良关联。对PDI与单独甲基汞或单独营养因素之间的关联进行的二次分析显示，30个月时，甲基汞与PDI之间仅存在临界显著关联，与营养因素无关。在5个月大的一个实验措施是积极的碘状态，但没有产前甲基汞暴露。这些研究结果表明，在研究产前甲基汞暴露与儿童发育结果之间关系的研究中，母亲营养可能起到混杂作用。(C)2008年爱思唯尔公司All rights reserved.
Fish contain nutrients that promote optimal brain growth and development but also contain methylmercury (MeHg) that can have toxic effects. The present study tested the hypothesis that the intake of selected nutrients in fish or measures of maternal nutritional status may represent important confounders when estimating the effects of prenatal methylmercury exposure on child development. The study took place in the Republic of Seychelles, an Indian ocean archipelago where fish consumption is high. A longitudinal cohort study design was used. A total of 300 mothers were enrolled early in pregnancy. Nutrients considered to be important for brain development were measured during pregnancy along with prenatal MeHg exposure. The children were evaluated periodically to age 30 months. There were 229 children with complete outcome and covariate data for analysis. The primary endpoint was the Bayley Scales of Infant Development-II (BSID-II), administered at 9 and 30 months of age. Combinations of four secondary measures of infant cognition and memory were also given at 5,9 and 25 months. Cohort mothers consumed an average of 537 g of fish (nine meals containing fish) per week. The average prenatal MeHg exposure was 5.9 ppm in maternal hair. The primary analysis examined the associations between MeHg, maternal nutritional measures and children's scores on the BSID-II and showed an adverse association between MeHg and the mean Psychomotor Developmental Index (PDI) score at 30 months. Secondary analyses of the association between the PDI and only MeHg alone or nutritional factors alone showed only a borderline significant association between MeHg and the PDI at 30 months and no associations with nutritional factors. One experimental measure at 5 months of age was positively associated with iodine status, but not prenatal MeHg exposure. These findings suggest a possible confounding role of maternal nutrition in studies examining associations between prenatal MeHg exposures and developmental outcomes in children. (C) 2008 Elsevier Inc. All rights reserved.