Somatotopic mapping of natural upper- and lower-extremity movements and speech production with high gamma electrocorticography
Somatotopic mapping of natural upper- and lower-extremity movements and speech production with high gamma electrocorticography
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使用高伽马皮质电图绘制自然上肢和下肢运动以及言语产生的体位图
DOI：
10.1016/j.neuroimage.2013.04.102
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发表时间：
2013
期刊：
影响因子：
5.7
通讯作者：
Tonio Ball
中科院分区：
文献类型：
--
作者：
Iljina;Johanna Ruescher;Dirk-Matthias Altenmüller;Ad Aertsen;Andreas Schulze-Bonhage ;Tonio Ball
在癫痫的神经外科前诊断中，病理和雄辩皮层的精确描绘是必不可少的。然而，现有实验程序的一个局限性是，它们严格要求患者的积极合作，这并不总是可以实现的，特别是在婴儿和认知能力不足的患者中。在本研究中，我们评估了癫痫患者在自然、非实验行为中高伽马活动的皮质电图记录在定位上肢和下肢运动和语言功能方面的潜力，并将结果与皮质电刺激获得的结果进行了比较。观察到的效果是非常显著和功能特异性的，并且与运动皮层的体位组织非常吻合，无论是在侧凸区还是在辅助运动区。我们的方法显示出与先前从实验数据中获得的四肢运动相似的特异性和敏感性。我们首次量化了4例患者的非实验性下肢运动的高伽马的敏感性和特异性，并观察到与上肢相同的范围内的值（分析了6例患者）。然而，在三名被调查的患者中，与语言相关的反应仅表现出非常低的敏感性。目前的研究结果表明，根据在自然行为中观察到的与事件相关的高伽马反应，不仅上肢而且下肢的运动定位与电皮层刺激映射一致是可能的。因此，非实验测绘可以有效地应用于确定上肢和下肢运动功能的既定临床程序的辅助。
Precise delineation of pathological and eloquent cortices is essential in pre-neurosurgical diagnostics of epilepsy. A limitation of existing experimental procedures, however, is that they critically require active cooperation of the patient, which is not always achievable, particularly in infants and in patients with insufficient cognitive abilities. In the present study, we evaluated the potential of electrocorticographic recordings of high gamma activity during natural, non-experimental behavior of epilepsy patients to localize upper- and lower-extremity motor and language functions, and compared the results with those obtained using electrocortical stimulation. The observed effects were highly significant and functionally specific, and agreed well with the somatotopic organization of the motor cortex, both on the lateral convexity and in the supplementary motor area. Our approach showed a similar specificity and sensitivity for extremity movements as previously obtained from experimental data. We were able to quantify, for the first time, sensitivity and specificity of high gamma underlying non-experimental lower-extremity movements in four patients, and observed values in the same range as for upper extremities (analyzed in six patients). Speech-related responses in the three investigated patients, however, exhibited only a very low sensitivity. The present findings indicate that localization of not only upper- but also lower-extremity movements congruent with electrocortical stimulation mapping is possible based on event-related high gamma responses that can be observed during natural behavior. Thus, non-experimental mapping may be usefully applied as adjunct to established clinical procedures for identification of both upper- and lower-extremity motor functions.
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影响因子：
2.9
作者：
Leuthardt EC;Pei XM;Breshears J;Gaona C;Sharma M;Freudenberg Z;Barbour D;Schalk G
通讯作者：
Schalk G
影响因子：
1.6
作者：
Aoki, F;Fetz, EE;Ojemann, GA
通讯作者：
Ojemann, GA
影响因子：
14.5
作者：
Sinai, A;Bowers, CW;Crone, NE
通讯作者：
Crone, NE
人类运动和感觉皮层：通过慢性硬膜下刺激研究地形。
影响因子：
4.8
作者：
Uematsu,S;Lesser,R;Fisher,RS;Gordon,B;Hara,K;Krauss,GL;Vining,EP;Webber,RW
通讯作者：
Webber,RW
非均匀的高γ（60-500 Hz）功率改变了人皮层中的认知任务和解剖结构。
DOI：
10.1523/jneurosci.4722-10.2011
发表时间：
2011-02-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gaona CM;Sharma M;Freudenburg ZV;Breshears JD;Bundy DT;Roland J;Barbour DL;Schalk G;Leuthardt EC
通讯作者：
Leuthardt EC