Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information.
Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information.
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DOI：
10.1016/j.neuroimage.2015.06.066
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发表时间：
2015-10-15
期刊：
影响因子：
5.7
通讯作者：
Beste C
中科院分区：
文献类型：
--
作者：
Dharmadhikari S;Ma R;Yeh CL;Stock AK;Snyder S;Zauber SE;Dydak U;Beste C
选择适当的反应是一项复杂的奋进，需要整合许多不同来源的信息在额-纹状体-丘脑电路。一个经常被忽视但相关的信息是由关于我们肢体当前位置的本体感受输入提供的。本研究使用GABA编辑的磁共振波谱（GABAMRS）和Simon任务（在健康受试者中具有本体感受诱导的干扰）检查纹状体和丘脑GABA水平在这些过程中的重要性。作为一个可能的模型缺陷的处理本体感受信息，我们也包括帕金森病（PD）患者在这项研究中。结果表明，本体感受信息不寻常的姿势复杂的反应选择过程中的控制，但不是在PD患者。众所周知的缺陷PD患者在处理本体感受信息可以变成一个好处时，改变本体感受信息通常会复杂的反应选择过程。纹状体和丘脑GABA水平在本体感受信息的反应选择过程的调制中发挥不可分割的作用：纹状体GABA水平似乎对反应的一般速度很重要，最有可能是因为纹状体GABA促进反应选择。相反，本体感受信息对反应冲突的调制与丘脑GABA浓度密切相关，浓度越高，反应冲突效应越小。对这一发现最可能的解释是，丘脑参与了感觉运动、注意力和认知信息的整合，以形成反应。然而，当对照组和PD患者分别进行分析时，丘脑中的这种效应消失了。
The selection of appropriate responses is a complex endeavor requiring the integration of many different sources of information in fronto-striatal-thalamic circuits. An often neglected but relevant piece of information is provided by proprioceptive inputs about the current position of our limbs. This study examines the importance of striatal and thalamic GABA levels in these processes using GABA-edited magnetic resonance spectroscopy (GABAMRS) and a Simon task featuring proprioception-induced interference in healthy subjects. As a possible model of deficits in the processing of proprioceptive information, we also included Parkinson's disease (PD) patients in this study. The results show that proprioceptive information about unusual postures complicates response selection processes in controls, but not in PD patients. The well-known deficits of PD patients in processing proprioceptive information can turn into a benefit when altered proprioceptive information would normally complicate response selection processes. Striatal and thalamic GABA levels play dissociable roles in the modulation of response selection processes by proprioceptive information: Striatal GABA levels seem to be important for the general speed of responding, most likely because striatal GABA promotes response selection. In contrast, the modulation of response conflict by proprioceptive information is closely related to thalamic GABA concentrations with higher concentration being related to a smaller response conflict effect. The most likely explanation for this finding is that the thalamus is involved in the integration of sensorimotor, attentional, and cognitive information for the purpose of response formation. Yet, this effect in the thalamus vanishes when controls and PD patients were analyzed separately.