Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling
Receptor for Advanced Glycation End Products Regulates Leukotriene B4 Receptor 1 Signaling
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DOI：
10.1089/dna.2016.3552
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发表时间：
2016-12-01
影响因子：
3.1
通讯作者：
Yokomizo, Takehiko
中科院分区：
文献类型：
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作者：
Ichiki, Takako;Koga, Tomoaki;Yokomizo, Takehiko
白三烯 B-4 受体 1 (BLT1) 是白三烯 B-4 (LTB4) 的高亲和力 G 蛋白偶联受体 (GPCR)，在炎症和免疫反应中发挥重要作用。尽管已知 LTB4-BLT1 轴会促进炎症，但调节 LTB4-BLT1 信号传导的结合蛋白尚未确定。最近，我们发现晚期糖基化终产物受体 (RAGE) 与 BLT1 相互作用并调节 LTB4-BLT1 信号传导。我们建议 RAGE 作为一类新型 GPCR 调节剂和未来 GPCR 研究的新目标。
Leukotriene B-4 receptor 1 (BLT1), a high-affinity G protein-coupled receptor (GPCR) for leukotriene B-4 (LTB4), plays important roles in inflammatory and immune reactions. Although the LTB4-BLT1 axis is known to promote inflammation, the binding proteins that modulate LTB4-BLT1 signaling have not been identified. Recently, we discovered that receptor for advanced glycation end products (RAGE) interacts with BLT1 and modulates LTB4-BLT1 signaling. We propose RAGE as a new class of GPCR modulator and a new target of future GPCR studies.