Effects of sulfate group in red seaweed polysaccharides on anticoagulant activity and cytotoxicity
Effects of sulfate group in red seaweed polysaccharides on anticoagulant activity and cytotoxicity
复制标题
红海藻多糖中硫酸基团的抗凝血活性和细胞毒性的影响
DOI：
10.1016/j.carbpol.2013.10.010
复制
发表时间：
2014-01-30
影响因子：
11.2
通讯作者：
Tang, Shunqing
中科院分区：
文献类型：
--
作者：
Liang, Wanai;Mao, Xuan;Tang, Shunqing
In this paper, the structural effects of two main red seaweed polysaccharides (agarose and carrageenan) and their sulfated derivatives on the anticoagulant activity and cytotoxicity were investigated. The substitution position rather than the substitution degree of sulfate groups shows the biggest impact on both the anticoagulant activity and the cell proliferation. Among them, C-2 of 3,6-anhydro-alpha-D-Galp is the most favorable position for substitution, whereas C-6 of beta-D-Galp is the most disadvantageous. Moreover, the secondary structures of glycans also play a key role in biological activities. These demonstrations warrant that the red seaweed polysaccharides should be seriously considered in biomedical applications after carefully tailoring the sulfate groups. (C) 2013 Elsevier Ltd. All rights reserved.
