AGE-DEPENDENT GLOMERULAR DAMAGE IN THE RAT - DISSOCIATION BETWEEN GLOMERULAR INJURY AND BOTH GLOMERULAR HYPERTENSION AND HYPERTROPHY - MALE GENDER AS A PRIMARY RISK FACTOR
AGE-DEPENDENT GLOMERULAR DAMAGE IN THE RAT - DISSOCIATION BETWEEN GLOMERULAR INJURY AND BOTH GLOMERULAR HYPERTENSION AND HYPERTROPHY - MALE GENDER AS A PRIMARY RISK FACTOR
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DOI：
10.1172/jci117531
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发表时间：
1994-11-01
影响因子：
15.9
通讯作者：
BAYLIS, C
中科院分区：
文献类型：
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作者：
BAYLIS, C
随着年龄的增长，肾小球发生进行性损伤，这在男性中尤其明显，并且不是任何特定疾病过程的结果。在目前对大鼠进行的研究中，检查了成年（8个月）、老年（12个月）和老年（19个月）慕尼黑Wistar大鼠的肾小球功能和结构。研究了完整的雄性和雌性大鼠以及去势的雄性和雌性大鼠，以确定性激素在介导年龄依赖性肾小球损伤中的作用。完整的男性发展肾小球损伤和蛋白尿，而女性，完整和卵巢切除，和去势的男性受到保护，免受伤害。在任何组中，肾小球血压均不随年龄增长而升高，且与肾小球损伤无关。在所有组中，肾小球体积确实随着年龄的增长而增加，但与肾小球损伤无关。我们发现，雄激素的存在，而不是缺乏雌激素提供了发展的年龄依赖性肾小球损伤的危险因素。肾小球高血压和肾小球肥大都不是完整男性年龄依赖性肾小球损伤的主要机制。
The glomerulus develops progressive injury with advancing age which is particularly pronounced in males and is not the result of any specific disease process. In the present studies conducted in rats, glomerular function and structure were examined in adult (8 mo), elderly (12 mo), and old (19 mo) Munich Wistar rats. Intact males and females and castrated rats of both sexes were studied to determine the role of the sex hormones in mediating age-dependent glomerular damage. Intact males developed glomerular injury and proteinuria whereas females, both intact and ovariectomized, and castrated males were protected from injury. Glomerular blood pressure did not increase with advancing age in any group and did not correlate with glomerular damage. Glomerular volume did increase with advancing age in all groups but did not correlate with glomerular damage. We found that the presence of the androgens rather than the absence of the estrogens provide the risk factor for development of age-dependent glomerular damage. Neither glomerular hypertension nor glomerular hypertrophy provide the primary mechanism by which age-dependent glomerular injury occurs in the intact male.