Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils
Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils
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DOI：
10.1111/j.1349-7006.2003.tb01426.x
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发表时间：
2003-03-01
期刊：
影响因子：
5.7
通讯作者：
Tatematsu, M
中科院分区：
文献类型：
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作者：
Nozaki, K;Shimizu, N;Tatematsu, M
已知幽门螺杆菌（Hp）感染与胃癌发生有密切关系，但根除Hp对Hp相关胃癌发生的影响尚未得到充分的实验研究。为了评价根除对胃癌发生的影响，利用感染Hp并经N-甲基-N-亚硝基脲（MNU）处理的蒙古沙鼠，研究了早期、中期和晚期根除的实验模型。将动物分为七组：A组（MNU+Hp+15周时根除）、B组（MNU+Hp+35周时根除）、C组（MNU+Hp+55周时根除）、D组（MNU+Hp）、E组（MNU）、F组（Hp）和G组（对照）。 75周时早期（A组）、中期（B组）和晚期（Q组）根除组肿瘤发生率分别为6.7%、27.3%和38.2%。未根除组（D组）发生率最高为56.3%。E组、F组和G组肿瘤发生率分别为6.3%、0.0%和0.0%。与Hp感染引起的炎症状态时期有关，Hp感染强烈增强化学致癌剂引发的胃癌的发生，并且在早期根除炎症后，这种增强作用被有效降低，这可能有效地预防Hp相关的胃癌发生。
Helicobacter pylori (Hp) infection and gastric carcinogenesis are known to have a close relationship, but the effect of eradication of Hp on Hp-related gastric carcinogenesis has not been fully studied experimentally. To evaluate the effect of eradication in gastric carcinogenesis, an experimental model with eradication in the early, middle or late period was studied using Hp-infected and N-methyl-N-nitrosourea (MNU)-treated Mongolian gerbils. The animals were divided into seven groups: group A (MNU+Hp+eradication at 15 w), group B (MNU+Hp+eradication at 35 w), group C (MNU+Hp+eradication at 55,w), group D (MNU+Hp), group E (MNU), group F (Hp) and group G (control). The tumor incidences at week 75 in the early (group A), middle (group B) and late (group Q eradicated groups were 6.7%, 27.3% and 38.2%, respectively. The incidence of 56.3% in the non-eradicated group was the highest (group D). Incidences in group E, group F and group G were 6.3%, 0.0% and 0.0%, respectively. The tumor incidences were related to the period of inflammatory status induced by Hp infection. Hp infection strongly enhanced gastric carcinogenesis initiated with a chemical carcinogen, and following eradication at an early period this enhancing effect was effectively reduced. Eradication at an early stage of inflammation might be effective in preventing Hp-related gastric carcinogenesis.