Hippocampal theta‐driving cells revealed by Granger causality
Hippocampal theta‐driving cells revealed by Granger causality
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DOI：
10.1002/hipo.22012
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发表时间：
2012-08
期刊：
影响因子：
3.5
通讯作者：
Lu Zhang;Guifen Chen;Ruifang Niu;Wei Wei-Wei;Xiaoyu Ma;Jiamin Xu;Jingyi Wang;Zhi-ru Wang;
中科院分区：
文献类型：
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作者：
Lu Zhang;Guifen Chen;Ruifang Niu;Wei Wei-Wei;Xiaoyu Ma;Jiamin Xu;Jingyi Wang;Zhi-ru Wang;
海马 CA1 区 θ 生成的双偶极模型表明，抑制性周膜 θ 偶极子是由局部 GABA 能中间神经元生成的。各种 CA1 中间神经元优先在不同的 θ 相位放电，这就提出了这些 θ 锁定的中间神经元如何促进 θ 振荡的产生的问题。我们在这里记录了自由行为小鼠海马 CA1 区的中间神经元，并通过使用格兰杰因果关系方法识别了 θ 锁定中间神经元的独特子集。这些细胞在探索过程中以极其可靠的 theta 爆发模式以高发射频率（〜90 Hz）发射，并且始终锁定在 theta 波的上升阶段。在我们记录的 θ 锁定中间神经元中，只有这些细胞对 θ 频带（4-12 Hz）内的局部场电位（LFP）信号产生强烈的格兰杰因果影响，并且这种影响在不同的行为状态下都持续存在。我们的结果表明，这种独特类型的 θ 锁定中间神经元在塑造海马 θ 振荡中充当局部抑制 θ 偶极控制细胞。 © 2012 Wiley 期刊公司。
The two‐dipole model of theta generation in hippocampal CA1 suggests that the inhibitory perisomatic theta dipole is generated by local GABAergic interneurons. Various CA1 interneurons fire preferentially at different theta phases, raising the question of how these theta‐locked interneurons contribute to the generation of theta oscillations. We here recorded interneurons in the hippocampal CA1 area of freely behaving mice, and identified a unique subset of theta‐locked interneurons by using the Granger causality approach. These cells fired in an extremely reliable theta‐burst pattern at high firing rates (∼90 Hz) during exploration and always locked to ascending phases of the theta waves. Among theta‐locked interneurons we recorded, only these cells generated strong Granger causal influences on local field potential (LFP) signals within the theta band (4–12 Hz), and the influences were persistent across behavioral states. Our results suggest that this unique type of theta‐locked interneurons serve as the local inhibitory theta dipole control cells in shaping hippocampal theta oscillations. © 2012 Wiley Periodicals, Inc.