Glutathione levels in human tumors.
Glutathione levels in human tumors.
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DOI：
10.3109/1354750x.2012.715672
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Colvin OM
中科院分区：
文献类型：
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作者：
Gamcsik MP;Kasibhatla MS;Teeter SD;Colvin OM
本文综述了在脑癌、乳腺癌、胃肠道癌、妇科癌、头颈癌和肺癌患者肿瘤组织中测定谷胱甘肽的临床研究。谷胱甘肽在乳腺癌、卵巢癌、头颈癌和肺癌中的含量往往会升高，而在脑瘤和肝癌中的含量则会低于无病组织。宫颈癌、结直肠癌、胃癌和食管癌的肿瘤谷胱甘肽水平均有高低。一些研究表明患者生存与肿瘤谷胱甘肽呈反比关系。基于这一调查，我们推荐可能提高谷胱甘肽作为生物标志物的临床价值的方法。
This review summarizes clinical studies in which glutathione was measured in tumor tissue from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung cancer. Glutathione tends to be elevated in breast, ovarian, head and neck and lung cancer and lower in brain and liver tumors compared to disease-free tissue. Cervical, colorectal, gastric and esophageal cancers show both higher and lower levels of tumor glutathione. Some studies show an inverse relationship between patient survival and tumor glutathione. Based on this survey, we recommend approaches that may improve the clinical value of glutathione as a biomarker.