Relationship Between Anemia and Systemic Inflammation in People Living With HIV and Tuberculosis: A Sub-Analysis of the CADIRIS Clinical Trial.
Relationship Between Anemia and Systemic Inflammation in People Living With HIV and Tuberculosis: A Sub-Analysis of the CADIRIS Clinical Trial.
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DOI：
10.3389/fimmu.2022.916216
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
艾滋病毒感染者（PWH）患活动性结核病（TB）的风险增加，贫血是这两种情况的常见并发症。结核病患者的贫血与免疫激活、血液中炎症生物标志物水平以及艾滋病毒疾病进展和死亡风险有关。在这项研究中，我们发现贫血与HIV-TB合并感染者中更明显的炎症特征相关，该研究招募了159名晚期HIV疾病患者（CD 4计数< 100个细胞/微升）作为随机临床试验（NCT 00988780）的一部分。在开始联合抗逆转录病毒治疗（cART）前获得的血浆中评估了一组血浆生物标志物。我们进行了一系列的多维分析，包括临床变量和炎症生物标志物的浓度，以描述PWH伴和不伴贫血的全身炎症。我们观察到，结核病参与者的血红蛋白水平比非结核病参与者低。这些参与者还表现出较高的炎症扰动程度（DIP）评分，与IFN-γ和TNF水平升高相关。DIP与cART启动前的TB合并感染和贫血相关。未来的机制研究是必要的，以评估这种协会的决定因素和治疗结果的影响。
People with HIV (PWH) are at increased risk of developing active tuberculosis (TB), and anemia is a common complication in both conditions. Anemia in TB patients has been linked to immune activation, levels of inflammatory biomarkers in blood, and risk for HIV disease progression and death. In this study we show that anemia was associated with a more pronounced inflammatory profile in HIV-TB coinfected persons in a cohort of 159 individuals with advanced HIV disease (CD4 count < 100 cells/µL) recruited as part of a randomized clinical trial (NCT00988780). A panel of plasma biomarkers was assessed on plasma obtained prior to combination antiretroviral therapy (cART) initiation. We performed a series of multidimensional analyses including clinical variables and concentrations of inflammatory biomarkers to profile systemic inflammation of PWH with and without anemia. We observed that TB participants presented with moderately lower levels of hemoglobin than non-TB participants. These participants also presented a higher Degree of Inflammatory Perturbation (DIP) score, related to increased levels of IFN-γ and TNF. The DIP was associated with TB coinfection and anemia before cART initiation. Future mechanistic studies are warranted to assess the determinants of such associations and the implications on treatment outcomes.
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DOI：
10.1016/s2352-3018(14)70027-x
发表时间：
2014-11-01
期刊：
The lancet. HIV
影响因子：
--
作者：
Sierra-Madero JG;Ellenberg S;Rassool MS;Tierney A;Belaunzarán-Zamudio PF;López-Martínez A;Piñeirúa-Menéndez A;Montaner LJ;Azzoni L;Benítez CR;Sereti I;Andrade-Villanueva J;Mosqueda-Gómez JL;Rodriguez B;Sanne I;Lederman MM;CADIRIS study team
通讯作者：
CADIRIS study team
影响因子：
11
作者：
Obirikorang C;Yeboah FA
通讯作者：
Yeboah FA
影响因子：
3.7
作者：
Goncalves, Andre N. A.;Lever, Melissa;Nakaya, Helder, I
通讯作者：
Nakaya, Helder, I
影响因子：
6.4
作者：
Boulware, David R.;Hullsiek, Katherine Huppler;Sereti, Irini
通讯作者：
Sereti, Irini
影响因子：
3.8
作者：
Mocroft, A;Kirk, O;Lundgren, JD
通讯作者：
Lundgren, JD