Interaction of Sequential Stimuli Applied during the Relative Refractory Period in Relation to Determination of Fibrillation Threshold in the Canine Ventricle
Interaction of Sequential Stimuli Applied during the Relative Refractory Period in Relation to Determination of Fibrillation Threshold in the Canine Ventricle
复制标题
相对不应期施加的顺序刺激的相互作用与犬心室颤动阈值测定的关系
DOI：
10.1161/01.res.37.5.534
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发表时间：
1975
影响因子：
20.1
通讯作者：
G. Moe
中科院分区：
文献类型：
--
作者：
J. Tamargo;B. Moe;G. Moe
在相对不应期对心脏组织施加无效的刺激可以改变对随后立即刺激的反应。我们观察到三种反应模式可以共存于同一心脏不同部位的刺激。在第一种模式中，2 - 10倍于舒张阈值的刺激，如果太早施加而不能引起传播性反应，当同样强度的刺激提前10毫秒施加时就会有效。在第二种模式中，当同样强度的刺激在30毫秒之前出现时，刚刚施加到足以引起反应的刺激就无法引起反应。最后，在第三种模式中，两个相距10毫秒的刺激，在单独给予时都足够晚，无法产生传播反应，当它们一起应用时。这些结果与使用一系列刺激来评估心室颤动阈值有关。可能的解释是基于从难熔状态恢复的时间分散。
An ineffective stimulus applied to cardiac tissue within the relative refractory period can alter the response to an immediately subsequent stimulus. We observed three response patterns that can coexist at different sites of stimulation in the same heart. In the first pattern, a stimulus of two to ten times diastolic threshold, applied too early to elicit a propagated response, becomes effective when a stimulus of equal strength is delivered 10 msec earlier. In the second pattern, a stimulus applied just late enough to evoke a response fails to do so when a stimulus of equal strength precedes it by as much as 30 msec. Finally, in the third pattern, two stimuli, separated by 10 msec, both of which are late enough to be effective when they are given alone, fail to yield a propagated response when they are applied together. These results have a bearing on the use of trains of stimuli to assess the ventricular fibrillation threshold. Possible interpretations are based on the temporal dispersion of recovery from the refractory state.