Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies
Novel inflammatory markers associated with cognitive performance: Singapore Longitudinal Ageing Studies
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DOI：
10.1016/j.neurobiolaging.2015.12.002
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发表时间：
2016-03-01
影响因子：
4.2
通讯作者：
Ng, Tze-Pin
中科院分区：
文献类型：
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作者：
Gao, Qi;Camous, Xavier;Ng, Tze-Pin
我们确定并验证了几个新的炎症标记物的认知能力在社区生活的老年人。一项探索性研究（n = 83）将Luminex测定的177种炎症标志物与简易精神状态检查（MMSE）相关联，并在验证研究（n = 139）中确定了酶联免疫吸附测定（ELISA）的8种炎症标志物以及与MMSE、蒙特利尔认知评估（莫卡）和认知障碍的相关性。验证研究重复了可溶性白细胞介素-2受体α链（sIL-2 R α; p = 0.050），可溶性肿瘤坏死因子受体2（sTNFR 2; p = 0.002）和可溶性糖蛋白130（sgp 130; p = 0.026）与MMSE，以及sIL-2 R α（p = 0.019）和sgp 130（p < 0.001）与莫卡。sgp 130、sIL-2 R α和sTNFR 2三分位数与认知功能障碍有显著相关趋势。sgp 130（比值比[ OR] = 4.24，95%置信区间[CI] 0.96-18.8）、sIL-2 R α（OR = 3.94，95% CI 0.83-18.7）和sTNFR 2（OR = 7.58，95% CI 1.19-48.1）的高三分位数与低三分位数的关联估计值高度升高。sgp 130、sTNFR 2和sIL-2 R α是用于进一步研究的低认知表现的有希望的炎症标志物。(C)2016 Elsevier Inc. All rights reserved.
We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosorbent assay (ELISA) and correlations with MMSE, Montreal Cognitive Assessment (MoCA), and cognitive impairment in the validation study (n = 139). The validation study replicated the significant associations of soluble interleukin-2 receptor alpha chain (sIL-2R alpha; p = 0.050), soluble tumor necrosis factor receptor 2 (sTNFR2; p = 0.002) and soluble glycoprotein 130 (sgp130; p = 0.026) with MMSE, and sIL-2R alpha (p = 0.019) and sgp130 (p < 0.001) with MoCA. Significant trends of associations of tertiles of sgp130, sIL-2R alpha, and sTNFR2 were found with cognitive impairment. Highly elevated estimates of association of high versus low tertiles were obtained for sgp130 (odds ratio [ OR] = 4.24, 95% confidence interval [CI] 0.96-18.8), sIL-2R alpha (OR = 3.94, 95% CI 0.83-18.7), and sTNFR2 (OR = 7.58, 95% CI 1.19-48.1). sgp130, sTNFR2, and sIL-2R alpha are promising inflammatory markers of low cognitive performance for further investigation. (C) 2016 Elsevier Inc. All rights reserved.