rs2572431 Polymorphism on Chromosome 8 Is Associated With Individual Differences in Anxiety Related Coping Modes
rs2572431 Polymorphism on Chromosome 8 Is Associated With Individual Differences in Anxiety Related Coping Modes
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DOI：
10.3389/fpsyg.2019.01451
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发表时间：
2019-07-09
影响因子：
3.8
通讯作者：
Montag, Christian
中科院分区：
文献类型：
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作者：
Jung, Sonja;Sindermann, Cornelia;Montag, Christian
目的：遗传因素在焦虑相关应对和人格之间的相互作用中的作用一直是许多先前研究的主题。目前的研究集中在焦虑相关的应对模式，即压抑与敏感（即，认知回避与警惕性）和单核苷酸多态性（SNP）rs 2572431。该SNP与焦虑相关人格特质之间的关联先前已在全基因组关联研究中显示，因此进一步调查该SNP与焦虑相关应对之间的关系似乎是必要的。（n = 269名男性，n = 611名女性;平均年龄：23.88，SD = 7.19）填写了一份性格问卷，评估认知回避和警惕性的个体差异，所有参与者均进行了rs 2572431基因分型。结果：在所有测试场景中，rs 2572431中T等位基因纯合子的参与者显示出最高的警惕性评分。这与早期全基因组关联研究的结果一致，该研究表明T等位基因也与较高的神经质评分相关。结论：当前的研究为rs 2572431在应对模式的分子遗传基础中的作用提供了证据，更广泛地说，它与人格的联系。
Objective: The role of genetic factors in the interplay between anxiety-related coping and personality has been the subject of interest in numerous previous studies. The current study focused on anxiety-related coping modes, namely repression versus sensitization (i.e., cognitive avoidance versus vigilance), and the single nucleotide polymorphism (SNP) rs2572431. An association between this SNP and anxiety-related personality traits has previously been shown in a genome wide association study, thus further investigation of the relationship between this SNP and anxiety-related coping seems warranted.Methods: In the present study, N = 880 mostly Caucasian participants (n = 269 males and n = 611 females; mean-age: 23.88, SD = 7.19) filled in a personality questionnaire assessing individual differences in cognitive avoidance and vigilance, and all participants were genotyped for rs2572431.Results: Participants homozygous for the T-allele in rs2572431 showed the highest vigilance scores in all scenarios tested. This is in line with findings from an earlier genome wide association study demonstrating that the T-allele is also associated with higher neuroticism scores.Conclusion: The current study yields evidence for the role of rs2572431 in the molecular genetic underpinnings of coping modes and, more broadly, for its connection with personality.