INFLUENCE OF SERUM-CHOLESTEROL AND ALBUMIN ON PARTITIONING OF PCB CONGENERS BETWEEN HUMAN-SERUM AND ADIPOSE-TISSUE
INFLUENCE OF SERUM-CHOLESTEROL AND ALBUMIN ON PARTITIONING OF PCB CONGENERS BETWEEN HUMAN-SERUM AND ADIPOSE-TISSUE
复制标题
DOI：
10.1016/0041-008x(87)90083-4
复制
发表时间：
1987-01-01
影响因子：
3.8
通讯作者：
ROHDE, CA
中科院分区：
文献类型：
--
作者：
GUO, YL;EMMETT, EA;ROHDE, CA
使用回归分析评估了血清脂质和蛋白质对人体血清和脂肪组织脂质之间单个多氯联苯（PCB）同系物峰分配的影响。受试者是55名维修工人谁是目前或以前暴露，和56个比较工人没有职业暴露于多氯联苯。七种同系物（2，4，5，4“-四CB、2，3，5，2”，3“，6”-六CB、2，3，4，2“，3”，6“-六CB、2，3，4，2”，4“，5”-六CB、3，4，5，3“，4”-五CB、2，3，4，5，2“，3”，4“-七CB和2，3，4，5，2”，3“，4”，选择在至少三分之一的总研究群体中的血清和脂肪组织中定量的5“-octa CB）进行评价。最初，血清PCB和某些候选变量之间的粗相关性进行了评估，一个以上的同源物与血清胆固醇，白蛋白，甘油三酯，低密度脂蛋白，极低密度脂蛋白，年龄，体脂含量和平均每天吃鱼。对血清同系物浓度对数与脂肪同系物浓度对数以及这些变量进行逐步回归。只有胆固醇、白蛋白和平均每天吃鱼的量对至少一个同系物峰值有意义。同系物的行为分为两组，这取决于它们的色谱洗脱顺序。对于2，4，5，4 ''-四氯苯、2，3，5，2 ''，3 ''，6 ''-六氯苯和2，3，4，2 ''，3 ''，6 ''-六氯苯，血清浓度的对数与脂肪同系物浓度的对数没有显著相关性，并且对于重要的候选变量没有一致的模式。对于同系物2，3，4，2 ''，4 ''，5 ''-六氯苯、3，4，5，3 ''，4 ''-五氯苯、2，3，4，5，2 ''，3 ''，4 ''-七氯苯和2，3，4，5，2 ''，3 ''，4 ''，5 ''-八氯苯，血清同系物浓度对数与脂肪同系物浓度对数和血清胆固醇呈显著正相关，血清白蛋白呈阴性。对于这四种同系物，单独使用脂肪同系物浓度对血清同系物浓度变异的解释（R2）分别为3%、23%、20%和30%，加入胆固醇和白蛋白后分别为13%、56%、43%和46%。因此，我们得出结论，血清胆固醇和白蛋白可以影响血清和脂肪组织之间的分布或分配的多氯联苯。
The influence of serum lipids and proteins on partitioning of individual polychlorinated biphenyl (PCB) congener peaks between human serum and adipose tissue lipid was assessed using regression analysis. Subjects were 55 repair workers who were either currently or previously exposed, and 56 comparison workers without occupational exposure to PCBs. Seven congeners (2,4,5,4''-tetra CB, 2,3,5,2'',3'',6''-hexa CB, 2,3,4,2'',3'',6''-hexa CB, 2,3,4,2'',4'',5''-hexa CB, 3,4,5,3'',4''-penta CB, 2,3,4,5,2'',3'',4''-hepta CB, and 2,3,4,5,2'',3'',4'',5''-octa CB) which had been quantified in both serum and adipose tissue in at least one-third of the total study population were selected for evaluation. Initially the crude correlations between the serum PCB and certain candidate variables were assessed; more than one congener was correlated with serum cholesterol, albumin, triglycerides, low-density lipoproteins, very low-density lipoproteins, age, body fat content and average serving of fish per day. Stepwise regression of log serum congener concentration on log adipose congener concentration and these variables was performed. Only cholesterol, albumin and average servings of fish per day were significant for at least one congener peak. Congeners behaved in two groups, depending on their order of chromatographic elution. For 2,4,5,4''-tetra CB, 2,3,5,2'',3'',6''-hexa CB, and 2,3,4,2'',3'',6''-hexa CB, log serum concentration was not significantly correlated with log adipose congener concentration, and there was no consistent pattern for significant candidate variables. For congeners 2,3,4,2'',4'',5''-hexa CB, 3,4,5,3'',4''-penta CB, 2,3,4,5,2'',3'',4''-hepta CB, and 2,3,4,5,2'',3'',4'',5''-octa CB, log serum congener concentration was consistently significantly correlated with log adipose congener concentration and serum cholesterol positively, and with serum albumin negatively. For these four congeners the explanations of variation (R2) in serum congener concentration using adipose congener concentration alone were 3, 23, 20 and 30%, respectively, and after adding cholesterol and albumin were 13, 56, 43 and 46%. Thus we conclude that serum cholesterol and albumin can influence the distribution or partition of PCBs between serum and adipose tissue.