An advanced universal circulatory assist device for left and right ventricular support: First report of an acute in vivo implant.
An advanced universal circulatory assist device for left and right ventricular support: First report of an acute in vivo implant.
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用于左心室和右心室支持的先进通用循环辅助装置：关于急性体内植入的第一份报告。
DOI：
10.1016/j.xjon.2020.06.006
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Karimov, Jamshid H
中科院分区：
文献类型：
--
作者：
Miyamoto, Takuma;Kado, Yuichiro;Horvath, David J;Kuban, Barry D;Sale, Shiva;Fukamachi, Kiyotaka;Karimov, Jamshid H
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The Advanced ventricular assist device (Advanced VAD) is designed as a universal pump intended to prevent backflow in the event of pump stoppage, to maintain physiological pulse pressure, and to be used as both a left and right VAD. The purpose of this study was to evaluate the performance of the Advanced VAD as both a left and right VAD in an acute in vivo study in calves. The Advanced VAD was implanted through a median sternotomy in 5 healthy calves (weight, 71.4-91.2 kg) as a left VAD (n = 3) or a right VAD (n = 2). After implantation, hemodynamic parameters, including general performance and pump stoppage, were evaluated. The Advanced VAD was successfully implanted as a left and right VAD without cardiopulmonary bypass. The speed range of the Advanced VAD was 2500 to 3500 rpm as a left VAD and 2000 to 2500 rpm as a right VAD. Up to 4.3 L/min was achieved for both left and right VAD configurations. To demonstrate the automatic shut-off feature, the pump was stopped without clamping the outflow graft. The outflow graft was then clamped, which produced no significant changes in the arterial pressure waveform. The pulse pressures under the left VAD configuration were 38 mm Hg, 17 mm Hg, 14 mm Hg, and 16 mm Hg at baseline, 2500 rpm, 3000 rpm, and 3500 rpm, respectively. This acute in vivo study demonstrated the pump performance, anatomical fitting as both left VAD and right VAD, and regurgitant flow shut-off feature of the Advanced VAD. The Advanced ventricular assist device is a universal pump designed to be used as a left, right, and biventricular ventricular assist device and also has features to preserve arterial pulsatility and prevent regurgitant flow while the pump is off. We report here the first acute animal study of the universal Advanced ventricle assist device implanted through a median sternotomy in calves (n = 5). The pump kept the hemodynamics stable as both left (n = 3) and right (n = 2) heart support and had a regurgitant flow shut-off feature and offered potential pulse augmentation. LVAD, Left ventricular assist device; RVAD, right ventricular assist device; AoP, aortic pressure.