Decreased chromobox homologue 7 expression is associated with epithelial-mesenchymal transition and poor prognosis in cervical cancer.
Decreased chromobox homologue 7 expression is associated with epithelial-mesenchymal transition and poor prognosis in cervical cancer.
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染色体盒同源物7表达降低与宫颈癌上皮-间质转化和预后不良相关
DOI：
10.1515/med-2021-0015
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Li R
中科院分区：
文献类型：
--
作者：
Tian P;Zhang C;Ma C;Ding L;Tao N;Ning L;Wang Y;Yong X;Yan Q;Lin X;Wang J;Li R
本研究的目的是评估染色体盒同源物7（CBX 7）表达与宫颈癌（CC）上皮间质转化以及疾病预后的关系。免疫组化检测CBX 7、E-cad、Vim的表达。评价CBX 7、E-cad和Vim表达与CC常规临床病理特征的关系。宫颈癌组织中CBX 7和E-cad的阳性表达率均低于癌旁组织。此外，Vim表达水平更高。CBX 7表达与E-cad表达呈正相关，与Vim表达呈负相关。CBX 7与乳腺癌的临床分期、组织分化程度、淋巴结转移和血管浸润有关。与CBX 7表达低或高的患者相比，CBX 7表达阴性的患者的总生存率降低。多因素考克斯回归分析显示，CBX 7表达降低是CC预后不良的独立预测因子。总之，CBX 7的缺失与CC的组织学分化、淋巴结转移、血管浸润和不良预后相关。CBX 7可能是CC患者预后的独立预后因素。
The aim of this study was to evaluate the association of the chromobox homologue 7 (CBX7) expression with the epithelial–mesenchymal transition in cervical cancer (CC), as well as with the disease prognosis. CBX7, E-cadherin (E-cad), and vimentin (VIM) expression levels were detected with immunohistochemistry. The relationship between the expression of CBX7, E-cad, and VIM expression and conventional clinicopathological characteristics of CC were evaluated. The positive expression rates of CBX7 and E-cad in the CC tissues were lower than the adjacent non-tumorous cervical tissues. Moreover, the VIM expression level was higher. The CBX7 expression was positively correlated with the E-cad expression, whereas was negatively correlated with the VIM expression. Furthermore, CBX7 was associated with the disease clinical staging, histological differentiation, lymph node metastasis, and vascular invasion. Patients with negative CBX7 expression showed decreased overall survival rates compared with those with low or high CBX7 expression. Multivariate Cox regression analysis indicated that the decreased CBX7 expression was an independent predictor for the poor prognosis of CC. In conclusion, the absence of CBX7 is associated with the histologic differentiation, lymphatic metastasis, vascular invasion, and poor prognosis of CC. CBX7 may be an independent prognostic factor for the prognosis of CC patients.