Effects of source leukocyte collection on the immune system.
Effects of source leukocyte collection on the immune system.
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源白细胞采集对免疫系统的影响。
DOI：
10.1111/j.1423-0410.1982.tb01110.x
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发表时间：
1982
期刊：
影响因子：
2.7
通讯作者：
Ozer,H
中科院分区：
文献类型：
--
作者：
Orsini,F;Fitzpatrick,J;Cohen,E;Khurana,U;Michielson,C;Chadha,KC;Han,T;Ozer,H
本研究旨在评估源白细胞浓缩物采集可能对双袋血浆置换供体产生的任何免疫学影响。以往的研究表明，监测参数，如T与非T淋巴细胞亚群，显示没有异常值的捐助者多达500访问超过12年的时间。本研究表明，白细胞捐献的频率和总数不会影响观察到的淋巴细胞亚群和功能。未观察到特异性和非特异性刺激、自然杀伤（NK）细胞活性、淋巴细胞表面标志物和各种功能参数的显著变化。例如，与非单采供体相比，单采供体在NK细胞活性、人白细胞干扰素产生、B细胞的IgG合成以及IgG合成和混合淋巴细胞培养物的抑制百分比方面没有表现出差异。
This study was initiated in order to assess any immunologic effects that source leukocyte concentrate collection might have on double-bag plasmapheresis donors. Previous studies have shown that surveillance parameters, such as T versus non-T lymphocyte subpopulations, showed no abnormal values in donors with as many as 500 visits over a 12-year period. The present study demonstrates that the frequency and the total number of leukocyte donations do not effect the lymphocyte subpopulations and functions observed. No significant changes were noted for specific and nonspecific stimulation, natural killer(NK) cell activity, lymphocyte surface markers and a variety of functional parameters. For example, the apheresis donors manifested no differences in NK cell activity, human leukocyte interferon production, IgG synthesis by B cells and percent suppression of both IgG synthesis and mixed lymphocyte cultures, when compared to non-apheresed donors.