Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes
Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes
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DOI：
10.1136/bjo.2003.035345
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发表时间：
2004-08-01
影响因子：
4.1
通讯作者：
Yoshida, A
中科院分区：
文献类型：
--
作者：
Nagaoka, T;Kitaya, N;Yoshida, A
目的：目的：探讨2型糖尿病患者黄斑中心凹脉络膜血流（CBF）的变化，方法：采用激光多普勒血流仪检测70例2型糖尿病患者黄斑中心凹CBF，并与36例年龄、性别相匹配的正常人对照。将患者分为3组：无糖尿病视网膜病变（NDR）患者33例（33只眼），无黄斑水肿的非增殖性糖尿病视网膜病变（NPDR/MO-）患者20例（20只眼），NPDR/MO+患者17例（17只眼）。结果：对照组、NDR组、NPDR/MO-组和NPDR/MO+组的组平均CBF值分别为13.5（4.9）、9.4（2.5）、10.8（4.8）和5.6（2.0）（任意单位）。与对照组相比，NDR组的组平均CBF值降低（30.2%; P< 0.01）。NPDR/MO+组的平均CBF值也明显低于NPDR/MO-组（48.2%; p< 0.01）。结论：糖尿病患者，尤其是伴有黄斑水肿的患者，中心凹区域的CBF明显降低。
Aim: To investigate changes in choroidal blood flow (CBF) in the foveal region in patients with type 2 diabetes.Methods: Laser Doppler flowmetry was used to determine the CBF in the foveal region in 70 patients with type 2 diabetes and 36 age and sex matched healthy subjects ( control group). The patients were classified into three groups: 33 patients ( 33 eyes) with no diabetic retinopathy (NDR), 20 patients ( 20 eyes) with non-proliferative diabetic retinopathy and no macular oedema (NPDR/MO-), and 17 patients ( 17 eyes) with NPDR and MO (NPDR/MO+). Optical coherence tomography was also used to measure the foveal thickness.Results: The group averaged CBF values were 13.5 (4.9), 9.4 (2.5), 10.8 (4.8), and 5.6 (2.0) ( arbitrary units) in the control, NDR, NPDR/MO-, and NPDR/MO+ groups, respectively. The group averaged CBF values in the NDR group decreased (30.2%; p< 0.01) compared with the control group. The average CBF value in the NPDR/MO+ group was also significantly lower (48.2%; p< 0.01) compared with that in the NPDR/MO- group.Conclusion: The CBF in the foveal region significantly decreases in patients with diabetes, especially those with macular oedema.