Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval
Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval
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DOI：
10.1126/science.1085818
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发表时间：
2003-08-08
期刊：
影响因子：
56.9
通讯作者：
Pape, HC
中科院分区：
文献类型：
--
作者：
Seidenbecher, T;Laxmi, TR;Pape, HC
杏仁核海马回路在巴甫洛夫恐惧记忆中起着关键作用。我们同时记录了自由行为的恐惧条件小鼠的外侧杏仁核（LA）和海马CA1区的电活动。活动模式与条件和冷漠的感觉刺激和环境引起的恐惧行为有关。有节奏的同步活动在θ频率增加之间的LA和CA1恐惧条件反射，并成为显着的对抗条件性恐惧刺激和表达冻结行为。杏仁核海马网络中θ活动的同步化代表了条件性恐惧的神经元相关性，易于改善记忆提取过程中的神经元通信。
The amygdalohippocampal circuit plays a pivotal role in Pavlovian fear memory. We simultaneously recorded electrical activity in the lateral amygdala (LA) and the CA1 area of the hippocampus in freely behaving fear-conditioned mice. Patterns of activity were related to fear behavior evoked by conditioned and indifferent sensory stimuli and contexts. Rhythmically synchronized activity at theta frequencies increased between the LA and the CA1 after fear conditioning and became significant during confrontation with conditioned fear stimuli and expression of freezing behavior. Synchronization of theta activities in the amygdalohippocampal network represents a neuronal correlate of conditioned fear, apt to improve neuronal communication during memory retrieval.