Depression in the excitability of relay cells of lateral geniculate nucleus following saccadic eye movements in the cat.
Depression in the excitability of relay cells of lateral geniculate nucleus following saccadic eye movements in the cat.
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猫眼球扫视运动后外侧膝状核中继细胞兴奋性下降。
DOI：
10.1113/jphysiol.1975.sp011004
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
H. Noda
中科院分区：
文献类型：
--
作者：
H. Noda
1.本文研究了警觉猫扫视性眼球运动时外侧膝状体中继细胞的兴奋性。兴奋性通过视交叉电刺激时细胞的放电概率来评估。在眼球运动后的时间段内，通过从眼电图中的电位偏移触发刺激器并改变刺激脉冲的延迟来评价兴奋性的变化。2.根据细胞的反应特性和对视交叉刺激的耐受性，将细胞分为S细胞和T细胞。在静止模式视野中扫视时，T细胞呈现爆发性放电，而S细胞的放电则完全被抑制。3.当眼球运动发生在光下时，在扫视后150-200毫秒，S细胞和T细胞的兴奋性被抑制。然而，抑郁症并不是在完全黑暗的情况下发生的。4.抑郁症也发生在没有眼球运动的情况下，当图案化的视野以扫视的方式移动时。5. S细胞的抑制发生在一个抑制期。由于S细胞不直接从视网膜接收图像移动的信号，因此抑郁症是由于通过T神经节中继细胞通道传递的信号的复发性抑制。6. T细胞的抑制与爆发性放电同时发生。由于在此期间复发性抑制的有效性较低，因此抑制可能是由于同一细胞中同时发生的高频率放电导致测试脉冲的阶段性闭塞。7.在眼球运动后的一段时间内，通过外侧膝状体核的视觉信息传递的损伤已经结合扫视抑制的神经生理学基础进行了讨论。
1. The excitability of relay cells of the lateral geniculate nucleus during a saccadic eye movement was studied in alert cats. Excitability was assessed by the firing probability of the cells in response to electrical stimulation of the optic chiasm. Modifications in the excitability were evaluated during the period following eye movements, by triggering a stimulator from potential shifts in electro‐oculogram and altering delays in the stimulus pulse. 2. The cells were classified into S and T cells, based on their response properties and the latencies to chiasmatic stimulation. With a saccade in a stationary patterned field, T cells showed a burst discharge, while the discharges of S cells were completely suppressed. 3. The excitability was depressed in both S and T cells for 150–200 msec after a saccade, when the eye movement occurred in light. However, the depression did not occur in complete darkness. 4. The depression occurred also in the absence of eye movement, when the patterned visual field was moved in a saccadic fashion. 5. The depression in S cells occurred during an inhibitory period. Since S cells do not receive signals on image movement directly from the retina, the depression was due to a recurrent inhibition by signals transferred through the T ganglion‐relay cell channel. 6. The depression in T cells occurred concomitantly with the burst discharge. Since the recurrent inhibition was operating less effectively during the period, the depression may be due to a phasic occlusion of the test impulse by coincident high‐rate firings in the same cell. 7. The impairment in transmission of visual information through the lateral geniculate nucleus during the period following eye movements has been discussed in connexion with a neurophysiological basis for saccadic suppression.