Early life nutrition and metabolic programming
Early life nutrition and metabolic programming
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DOI：
10.1111/j.1749-6632.2010.05798.x
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Ozanne, Susan E.
中科院分区：
文献类型：
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作者：
Fernandez-Twinn, Denise S.;Ozanne, Susan E.
近年来，对成人代谢性疾病早期编程的研究为早期环境如何影响长期健康提供了许多机制见解。它包括解决宫内营养可用性的作用的研究，这是由孕产妇营养、孕产妇接触氧气、中毒事件和感染决定的；胎盘界面；以及出生后早期的环境。本综述将探讨代谢性疾病编程的流行病学证据，并概述各种利用动物模拟代谢表型结果的研究。它还将讨论提出的分子机制和潜在干预的证据。
Research investigating the early programming of adult metabolic disease has in recent years provided much mechanistic insight into how the early environment impacts on long-term health. It includes studies addressing the roles of intrauterine nutrient availability, which is determined by maternal nutrition, maternal exposure to oxygen, toxic events, and infection; the placental interface; and also the early postnatal environment. This review will explore the epidemiological evidence for programming of metabolic disease and provide an overview of the various studies using animals to model metabolic phenotypic outcome. It will also discuss evidence for the proposed molecular mechanisms and the potential for intervention.