Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder
Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder
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DOI：
10.1097/00001756-199805110-00038
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发表时间：
1998-05-11
期刊：
影响因子：
1.7
通讯作者：
Rattray, M
中科院分区：
文献类型：
--
作者：
Oddiah, D;Anand, P;Rattray, M
神经生长因子(NGF)是痛觉过敏的中介物，以前被认为与膀胱炎后的感觉和反射改变有关。建立了一种灵敏的方法来检测松节油引起的短暂的炎症反应引起的膀胱炎后神经营养素基因的表达。致炎后2小时，NGF、脑源性神经营养因子和神经营养因子-3mRNAs水平显著升高，而6小时和24小时未见明显变化。NGF免疫反应增强，与其mRNA表达的时程相似。我们的结果表明，在膀胱炎症过程中，内源性NGF迅速上调并释放，以调节感觉和反射的变化。脑源性神经营养因子和神经营养因子-3也可能在炎症反应中发挥作用。(C)1998年Rapid Science Ltd.
NERVE growth factor (NGF) is a mediator of hyperalgesia and has been previously associated with sensory and reflex changes after inflammation of the urinary bladder. A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short-lived inflammatory response. Two hours, but not 6 or 24 h after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs. NGF immunoreactivity was elevated with a similar time course to its mRNA. Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes. Brain-derived neurotrophic factor and neurotrophin-3 may also have a role in the inflammatory response. (C) 1998 Rapid Science Ltd.