Composite Scaffolds of Gelatin and Fe3O4 Nanoparticles for Magnetic Hyperthermia-Based Breast Cancer Treatment and Adipose Tissue Regeneration
Composite Scaffolds of Gelatin and Fe3O4 Nanoparticles for Magnetic Hyperthermia-Based Breast Cancer Treatment and Adipose Tissue Regeneration
复制标题
明胶和 Fe3O4 纳米颗粒复合支架用于磁热疗乳腺癌治疗和脂肪组织再生
DOI：
10.1002/adhm.202202604
复制
发表时间：
2023
影响因子：
10
通讯作者：
Yang Yingnan,Chen Guoping.
中科院分区：
文献类型：
--
作者：
Sun Rui;Chen Huajian;Zheng Jing;Yoshitomi Toru;Kawazoe Naoki;Yang Yingnan,Chen Guoping.
乳腺癌的术后治疗仍然是一个挑战，关于杀死残留的癌细胞和再生乳房缺陷。为了制备术后使用的复合支架，用叶酸（FA）对明胶进行化学修饰，并将其与柠檬酸盐修饰的Fe3O4纳米颗粒（Fe3O4‐citrate NPs）杂交，制备出孔结构由自由冰微粒控制的Fe3O4/明胶复合支架。复合支架具有相互连接的大球形孔，以方便细胞进出。FA功能化的复合支架具有捕获乳腺癌细胞的能力。在交变磁场（AMF）照射下，Fe3O4/明胶复合支架具有高的磁热转换能力，可以消融乳腺癌细胞。此外，复合支架促进间充质干细胞的生长和脂肪形成。复合支架具有多种功能，既能在AMF照射下清除残留的癌细胞，又能在AMF关闭时使切除的脂肪组织再生。
Postsurgical treatment of breast cancer remains a challenge with regard to killing residual cancer cells and regenerating breast defects. To prepare composite scaffolds for postoperative use, gelatin is chemically modified with folic acid (FA) and used for hybridization with citrate‐modified Fe3O4nanoparticles (Fe3O4‐citrate NPs) to fabricate Fe3O4/gelatin composite scaffolds which pore structures are controlled by free ice microparticles. The composite scaffolds have large spherical pores that are interconnected to facilitate cell entry and exit. The FA‐functionalized composite scaffolds have the ability to capture breast cancer cells. The Fe3O4/gelatin composite scaffolds possess a high capacity for magnetic‐thermal conversion to ablate breast cancer cells during alternating magnetic field (AMF) irradiation. In addition, the composite scaffolds facilitate the growth and adipogenesis of mesenchymal stem cells. The composite scaffolds have multiple functions for eradication of residual cancer cells under AMF irradiation and for regeneration of resected adipose tissue when AMF is off.