The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms.
The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms.
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DOI：
10.1016/j.bpg.2010.08.008
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发表时间：
2010-12
影响因子：
3.2
通讯作者：
Orlando, Roy C.
中科院分区：
文献类型：
--
作者：
Orlando, Roy C.
关键词：
胃灼热是胃食管反流病最常见和最具特征性的症状。它最终是由于反流的胃酸与食管粘膜内的伤害感受器接触，并将这种外周信号传递到中枢神经系统进行认知。健康的食管上皮在反流的胃酸和食管伤害感受器之间提供了有效的屏障;但是这种屏障容易受到攻击和破坏，特别是酸性胃内容物。胃酸是如何被食管粘膜内的防御元素所抵消的，这是本文讨论的一个主要焦点。当防御成功时，受试者无症状，当防御失败时，受试者经历胃灼热。胃灼热通常分为三种内镜类型之一：非糜烂性反流病，糜烂性食管炎和巴雷特食管。虽然什么决定了内镜类型仍然未知，但本文提出炎症起着关键的调节作用。
Heartburn is the most common and characteristic symptom of gastroesophageal reflux disease. It ultimately results from contact of refluxed gastric acid with nociceptors within the esophageal mucosa and transmission of this peripheral signal to the central nervous system for cognition. Healthy esophageal epithelium provides an effective barrier between refluxed gastric acid and esophageal nociceptors; but this barrier is vulnerable to attack and damage, particularly by acidic gastric contents. How gastric acid is countered by defensive elements within the esophageal mucosa is a major focus of this discussion. When the defense is successful, the subject is asymptomatic and when unsuccessful, the subject experiences heartburn. Those with heartburn commonly fall into one of three endoscopic types: nonerosive reflux disease, erosive esophagitis and Barrett's esophagus. Although what determines endoscopic type remains unknown; it is proposed herein that inflammation plays a key, modulating role.
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发表时间：
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影响因子：
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