Determination of peptide conformation via vibrational coupling: application to diastereoisomeric alanyl dipeptides.
Determination of peptide conformation via vibrational coupling: application to diastereoisomeric alanyl dipeptides.
复制标题
通过振动耦合测定肽构象：应用于非对映异构丙氨酰二肽。
DOI：
10.1002/bip.360231008
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发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Alva,C
中科院分区：
文献类型：
--
作者：
Diem,M;Oboodi,MR;Alva,C
报道了非对映体丙氨酰二肽D-Ala-L-Ala和L-Ala-L-Ala以及各种单氘和双氘同位素在水和D2 O中的溶液相拉曼光谱。非对映异构体形式之间的光谱差异进行解释，使用耦合振荡器模型的拉曼模拟，在某些振动的非对映异构体形式之间的几何差异。耦合振子形式的应用允许确定耦合振动之间的二面角。结果进行了比较，与其他工作人员在测定肽的振动光谱的振动耦合。
Solution‐phase Raman spectra of diastereomeric alanyl dipeptides,D‐Ala‐L‐Ala andL‐Ala‐L‐Ala, and various mono‐ and dideuterated isotopomers in H2O and D2O, are reported. Spectral differences between the diastereomeric forms are interpreted, using the Raman analog of the coupled oscillator model, in terms of geometric differences between certain vibrations in the diastereomeric forms. Application of the coupled‐oscillator formalism allows the determination of a dihedral angle between the coupling vibrations. The results are compared with vibrational coupling employed by other workers in the determination of the vibrational spectra of peptides.