Executive function and suicidal risk in women with Borderline Personality Disorder
Executive function and suicidal risk in women with Borderline Personality Disorder
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DOI：
10.1016/j.psychres.2011.10.008
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发表时间：
2012-03-30
影响因子：
11.3
通讯作者：
Toplak, Maggie
中科院分区：
文献类型：
--
作者：
LeGris, Jeannette;Links, Paul S.;Toplak, Maggie
一系列执行功能（EF）缺陷与边缘型人格（BPD）有关，这是一种以高自杀率为特征的疾病。然而，EF和自杀风险在BPD中的作用尚未得到检验。本探索性研究比较了42名BPD女性和41名健康对照者的工作记忆、Stroop干扰、运动抑制（SSRT）和爱荷华赌博任务（IGT）决策表现。自杀行为问卷（Osman etal）评估EF对自杀风险的敏感性。（2001）也进行了测试。除决策能力外，BPD女性在所有EF方面的表现与对照组相似。然而，较弱的Stroop干扰控制是唯一显著的EF对自杀风险的贡献，与抑郁症的贡献几乎相当。EF和抑郁共同解释了总自杀风险调整方差的34%。与预期相反，IGT决策和运动抑制与总体自杀风险无关。除了抑郁或BPD严重程度外，只有Stroop干扰控制对终生自杀意图/企图有显著影响。由于先前的自杀企图仍然是未来企图的最强预测因子（Soloff等人，2003），因此stroop表现对自杀风险的敏感性可能在临床上具有重要意义。干扰控制可能代表了一种独立于精神病诊断的自杀“素质”。2012爱思唯尔爱尔兰有限公司版权所有。
A range of executive function (EF) deficits have been associated with Borderline Personality (BPD), a disorder characterized by high rates of suicide. However, the role of EF and suicide risk in BPD has not been examined. This exploratory study compared working memory, Stroop interference, motor inhibition (SSRT) and Iowa Gambling Task (IGT) decision making performance in 42 women with BPD and 41 healthy controls. The sensitivity of EF to suicidal risk as assessed by the Suicide Behaviour Questionnaire-R (Osman etal., 2001) was also tested. Women with BPD performed similar to controls on all EF except decision making. Weaker Stroop interference control, however, was the only significant EF contributor to suicide risk, demonstrating near equivalent contributions to that of depression. EF and depression collectively explained 34% of the adjusted variance in total suicide risk. Contrary to expectations, IGT decision making and motor inhibition were not associated with overall suicide risk. Only Stroop interference control contributed significantly to lifetime suicide intent/attempt beyond depression or BPD severity. As prior suicide attempt remains the strongest predictor of future attempt (Soloff et al., 2003), the sensitivity of stroop performance to suicidal risk may be clinically important. Interference control may represent a "diathesis" for suicide that is independent of psychiatric diagnoses. (C) 2012 Elsevier Ireland Ltd. All rights reserved.