Parameters Quantifying Dehydration in Canine Vocal Fold Lamina Propria
Parameters Quantifying Dehydration in Canine Vocal Fold Lamina Propria
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DOI：
10.1002/lary.20927
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发表时间：
2010-07-01
期刊：
影响因子：
2.6
通讯作者：
Jiang, Jack J.
中科院分区：
文献类型：
--
作者：
Hanson, Kevin P.;Zhang, Yu;Jiang, Jack J.
目的/假设：本研究的目的是测量的固体和液体的体积和质量的犬声带固有层组织在不同的脱水水平，并计算参数，以测试双相理论声带生理和biomechanics.Study Design：开放，对照，experimental trials.Methods：声带固有层解剖15犬喉，产生30个组织样本。测量组织样品的初始体积和质量。然后在30%、50%和70%脱水期间每2分钟测量组织样品的质量，其中10个样品经受三种处理中的每一种，然后完全脱水以产生组织的固体组分。液体的质量和体积分数和液体：固体的质量和体积比的声带固有层samples.Results：液体的质量和体积分数和液体：固体的质量和体积比是显着不同的，在每个脱水水平，除了液体：固体体积比在30%与50%脱水。线性回归分析表明，所有的固体和液体参数测量可以预测的脱水水平的基础上逆，线性relationships.Conclusions：这些结果提供了进一步的实验证据支持双相理论，并建议声带固有层组织脱水的程度可以量化的基础上的双相模型参数。
Objectives/Hypothesis: The goal of this study was to measure the solid and liquid volume and mass of canine vocal fold lamina propria tissue at varying dehydration levels, and to calculate parameters to test the biphasic theory of vocal fold physiology and biomechanics.Study Design: Open, controlled, experimental trial.Methods: The vocal fold lamina propria was dissected from 15 canine larynges, yielding 30 tissue samples. The initial volumes and masses of the tissue samples were measured. The masses of the tissue samples were then measured every 2 minutes during 30%, 50%, and 70% dehydration, with 10 samples subjected to each of the three treatments, followed by complete dehydration to yield the solid component of the tissue. The liquid mass and volume fractions and liquid:solid mass and volume ratios of the vocal fold lamina propria samples were calculated.Results: The liquid mass and volume fractions and liquid:solid mass and volume ratios were significantly different at each dehydration level, except for the liquid:solid volume ratios at 30% versus 50% dehydration. Linear regression analysis suggested that all of the solid and liquid parameters measured could be predicted by dehydration level based on inverse, linear relationships.Conclusions: These results provide further experimental evidence supporting the biphasic theory and suggest that the extent of vocal fold lamina propria tissue dehydration may be quantified based on the biphasic model parameters.