Platelet Activation in Psoriasis
Platelet Activation in Psoriasis
复制标题
牛皮癣中的血小板活化
DOI：
10.1055/s-0038-1661271
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发表时间：
1985
影响因子：
6.7
通讯作者：
G. Nenci
中科院分区：
文献类型：
--
作者：
M. Berrettini;P. Parise;V. Costantini;Serena Grasselli;G. Nenci
最近的流行病学研究表明，牛皮癣是血栓性血管疾病的危险因素。为了评估止血变化在银屑病血栓发作发展中的可能作用，我们对22例男性银屑病患者进行了止血“平衡”的一些参数调查，并与22例男性对照组进行了比较。已知血管疾病危险因素（糖尿病、高血压、吸烟、血脂异常）的发生率在两个研究组中具有可比性。两组在血小板计数、循环血小板聚集、血小板生成丙二醛（MDA）、血浆总抗凝血酶和纤溶活性方面差异无统计学意义。银屑病患者自发血小板高聚集率和血浆β-血栓球蛋白水平显著高于对照组。银屑病患者服用阿司匹林后，血小板再生时间（以丙二醛恢复来衡量）明显缩短。这些数据表明，体内血小板活化发生在银屑病患者，并可能有助于血栓性并发症的发展。活化血小板释放有丝分裂和炎症物质可能在银屑病病变的组织发生中起作用。
Summary Recent epidemiological studies have suggested that psoriasis represents a risk factor for thrombotic vascular diseases. In order to evaluate the possible role of hemostatic changes in the development of thrombotic episodes in psoriasis, some parameters of the hemostatic “balance” were investigated in 22 male psoriatic patients and compared to those of 22 male control subjects. Incidence of known risk factors for vascular diseases (diabetes, hypertension, smoking, dyslipidemia) was comparable in the two study groups. There were no statistically significant differences in platelet count, circulating platelet aggregates, platelet production of malondialdehyde (MDA), total plasma anti thrombin and fibrinolytic activities. In patients with psoriasis the incidence of spontaneous platelet hyperaggregability and plasma levels of β-thromboglobulin were significantly higher than in control subjects. Platelet regeneration time, measured as MDA recovery after aspirin ingestion, was significantly shorter in psoriatic patients. These data suggest that an in vivo platelet activation occurs in patients with psoriasis and could contribute to the development of thrombotic complications. The release of mitogenic and inflammatory substances by activated platelets may play a role in the histogenesis of psoriatic lesions.