Effects of working memory training on functional connectivity and cerebral blood flow during rest
Effects of working memory training on functional connectivity and cerebral blood flow during rest
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DOI：
10.1016/j.cortex.2012.09.007
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发表时间：
2013-09
期刊：
影响因子：
3.6
通讯作者：
H. Takeuchi;Y. Taki;R. Nouchi;H. Hashizume;A. Sekiguchi;Yuka Kotozaki;Seishu Nakagawa;Calros M. Miyauchi-Calros
中科院分区：
文献类型：
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作者：
H. Takeuchi;Y. Taki;R. Nouchi;H. Hashizume;A. Sekiguchi;Yuka Kotozaki;Seishu Nakagawa;Calros M. Miyauchi-Calros
工作记忆训练（WMT）改变了任务相关的大脑活动和外部注意系统（EAS）的结构。我们研究了WMT是否也会改变静息状态脑机制，这被认为反映了大脑的内在活动和连通性。我们的研究对象进行了为期4周的WMT计划，并在干预前后进行了脑部扫描，以确定休息期间功能连通性和区域脑血流的变化（静息- fc /静息- rcbf）。与未干预相比，WMT (a)增加了内侧前额叶皮层（mPFC）和叶前叶之间的静息- fc，这是默认模式网络（DMN）的关键节点；(b)减少了内侧前额叶皮层和右侧后顶叶皮层/右侧外侧前额叶皮层（LPFC）之间的静息- fc，这是EAS的关键节点；(c)增加了右侧LPFC的静息- rcbf。然而，训练相关的DMN关键节点和EAS节点之间的静息- fc下降仅在个体分析中全脑信号回归时观察到，而在个体分析中全脑信号未回归时未观察到这些变化。进一步的分析表明，这些差异可能是由EAS节点和大脑多个双侧区域活动之间的静息fc的微弱但广泛的增加所介导的。这些结果表明，WMT在休息时诱导DMN和EAS等神经机制的可塑性，表明认知训练可以影响大脑的内在活动和连通性。
Working memory (WM) training (WMT) alters the task-related brain activity and structure of the external attention system (EAS). We investigated whether WMT also alters resting-state brain mechanisms, which are assumed to reflect intrinsic brain activity and connectivity. Our study subjects were subjected to a 4-week WMT program and brain scans before and after the intervention for determining changes of functional connectivity and regional cerebral blood flow during rest (resting-FC/resting-rCBF). Compared with no-intervention, WMT (a) increased resting-FC between the medial prefrontal cortex (mPFC) and precuneus, which are key nodes of the default mode network (DMN), (b) decreased resting-FC between mPFC and the right posterior parietal cortex/right lateral prefrontal cortex (LPFC), which are key nodes of the EAS, and (c) increased resting-rCBF in the right LPFC. However, the training-related decreases in resting-FC between the key DMN node and the nodes of EAS were only observed when the whole brain signal was regressed out in individual analyses, and these changes were not observed when the whole brain signal was not regressed out in individual analyses. Further analyses indicated that these differences may be mediated by a weak but a widespread increase in resting-FC between the nodes of EAS and activity of multiple bilateral areas across the brain. These results showed that WMT induces plasticity in neural mechanisms involving DMN and the EAS during rest and indicated that intrinsic brain activity and connectivity can be affected by cognitive training.