A four-layer depth of interaction detector block for small animal PET
A four-layer depth of interaction detector block for small animal PET
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DOI：
10.1109/tns.2004.835739
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发表时间：
2004-10-01
影响因子：
1.8
通讯作者：
Orita, N
中科院分区：
文献类型：
--
作者：
Tsuda, T;Murayama, H;Orita, N
我们现在正计划开发一种专用于小动物（如大鼠和小鼠）的正电子发射断层扫描仪，以满足更高灵敏度的需求。对于正电子发射断层扫描（PET），我们新设计了一个四层的相互作用深度（DOI）探测器，它是由所有相同的晶体元件构成的。在该DOI探测器中，反射器的适当插入通过在晶体元件之间插入反射器来控制闪烁光子的行为，使得可以从由Anger型计算制成的一个二维（2-D）位置直方图中提取四个层的DOI信息。作为初步实验，我们测量了DOI探测器的晶体识别性能，该探测器由四层16 × 16晶体阵列组成，使用Ce浓度为0.5摩尔%的Gd 2SiO 5晶体。每个晶体的尺寸为1.42 mm x 1.42 mm x 4.5 mm。一个晶体块光学耦合到一个256通道平板位置敏感光电倍增管，其开口面积为52.0 mm x 52.0 mm。我们获得了足够的定位性能，这个四层DOI检测器的2-D位置直方图。我们认为，这将是一个很有前途的设备，实现一个小动物PET扫描仪具有高灵敏度和高分辨率。
We are now planning to develop a positron emission tomograph dedicated to small animals, such as rats and mice, which meets the demand for higher sensitivity. For the positron emission tomography (PET), we newly designed a four-layer depth of interaction (DOI) detector, which is constructed of all the same crystal elements. In this DOI detector, appropriate insertion of the reflector controls the behaviour of scintillation photons by inserting the reflectors between crystal elements so that the DOI information of four layers can be extracted from one two-dimensional (2-D) position histogram made by Anger-type calculation. As a preliminary experiment, we measured crystal identification performance of the DOI detector, which consists of four layers of a 16 x 16 crystal array using Gd2SiO5 crystals with Ce concentration of 0.5 mol %. Each crystal is in dimensions of 1.42 mm x 1.42 mm x 4.5 mm. A crystal block is optically coupled to a 256-channel flat panel position sensitive photomultiplier tube whose opening area is 52.0 mm x 52.0 mm. We obtained sufficient positioning performance for this four-layer DOI detector on the 2-D position histogram. We concluded that it would be a promising device to realize a small animal PET scanner with high sensitivity and high resolution.