Microscopic agents programmed by DNA circuits
Microscopic agents programmed by DNA circuits
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DOI：
10.1038/nnano.2016.299
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发表时间：
2017-04-01
影响因子：
38.3
通讯作者：
Rondelez, Y.
中科院分区：
文献类型：
--
作者：
Gines, G.;Zadorin, A. S.;Rondelez, Y.
存储在合成核酸序列中的信息可以在体外用于创建具有精确编程的化学动力学的复杂反应网络。在这里，我们将这种方法扩展到分散在酶溶液中的微观颗粒（代理）的网络。代理人可能拥有多个稳定的状态，从而保持记忆，并通过发射各种正交化学信号进行通信，同时还感测相邻代理人的行为。使用这种方法，我们可以产生涉及数千个代理的集体行为，例如长距离检索信息或创建空间模式。我们的系统概括了生物体之间分布式决策和形态发生的一些基本机制，并且可以在需要结合许多个体线索以做出决策的情况下找到应用，例如在分子诊断中。
Information stored in synthetic nucleic acids sequences can be used in vitro to create complex reaction networks with precisely programmed chemical dynamics. Here, we scale up this approach to program networks of microscopic particles (agents) dispersed in an enzymatic solution. Agents may possess multiple stable states, thus maintaining a memory and communicate by emitting various orthogonal chemical signals, while also sensing the behaviour of neighbouring agents. Using this approach, we can produce collective behaviours involving thousands of agents, for example retrieving information over long distances or creating spatial patterns. Our systems recapitulate some fundamental mechanisms of distributed decision making and morphogenesis among living organisms and could find applications in cases where many individual clues need to be combined to reach a decision, for example in molecular diagnostics.