Suboptimal lipoprotein (a) control and residual plaque instability despite proprotein convertase subtilisin/kexin type 9 inhibitor use in heterozygous familial hypercholesterolaemia: insights from serial near-infrared spectroscopy imaging
Suboptimal lipoprotein (a) control and residual plaque instability despite proprotein convertase subtilisin/kexin type 9 inhibitor use in heterozygous familial hypercholesterolaemia: insights from serial near-infrared spectroscopy imaging
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尽管在杂合子家族性高胆固醇血症中使用了前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型抑制剂，但脂蛋白 (a) 控制不佳且残留斑块不稳定性：来自连续近红外光谱成像的见解
DOI：
10.1093/eurheartj/ehab218
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发表时间：
2021
影响因子：
39.3
通讯作者：
Noguchi Teruo
中科院分区：
文献类型：
--
作者：
Imamoto Kazumasa;Kataoka Yu;Hosoda Hayato;Noguchi Teruo
一位患有杂合子家族性高胆固醇血症的63岁男性患者接受了冠状动脉造影和近红外光谱/血管内超声（DualPro，Nipro，日本）成像，以评价中度冠状动脉狭窄。该病变表现出广泛的超声信号衰减和大量的斑块，其最大脂核负荷指数（maxLCBI 4 mm）反映了这一点，
A 63-year-old gentleman with heterozygous familial hypercholesterolaemia received coronary angiography and near-infrared spectroscopy/intravascular ultrasound (DualPro, Nipro, Japan) imaging to evaluate an intermediate coronary stenosis. This lesion exhibited extensive ultrasonic signal attenuation and a substantial amount of lipidic plaque, reflected by its maximum lipidcore burden index (maxLCBI4mm) at