Coronary vascular response to adrenergic stimulation in exercise-conditioned dogs.
Coronary vascular response to adrenergic stimulation in exercise-conditioned dogs.
复制标题
运动条件下的狗对肾上腺素刺激的冠状血管反应。
DOI:
10.1152/jappl.1984.57.2.315
复制
发表时间:
1984
期刊:
影响因子:
--
通讯作者:
Stone,HL
中科院分区:
文献类型:
--
作者:
Gwirtz,PA;Stone,HL
The present study was designed to determine whether daily exercise alters adrenergic and muscarinic neural control of coronary blood flow during resting and exercising conditions in the conscious dog. Mean left circumflex artery blood flow (CBF), mean coronary blood pressure, and heart rate were measured during resting conditions (55 +/- 9 ml/min, 108 +/- 6 mmHg, and 93 +/- 2 beats/min, respectively) and during submaximal exercise (85 +/- 9 ml/min, 108 +/- 7 mmHg, and 210 +/- 15 beats/min). Injection of phentolamine into the left circumflex coronary artery during treadmill exercise resulted in a 10 +/- 1% increase in CBF before training (untrained, UT) and a 21 +/- 6% increase after 4–5 wk of daily exercise (partially trained, PT) (P less than 0.02 UT vs. PT). Intracoronary atenolol or propranolol caused a 15 +/- 6% reduction in CBF during exercise in dogs before and after PT. While the dogs were lying quietly at rest intracoronary injections of norepinephrine initially increased CBF 85%, followed by a prolonged 19 +/- 9% decrease in CBF. CBF decreased 16 +/- 3% after intracoronary injection of phenylephrine. After PT the coronary vasoconstriction following norepinephrine and phenylephrine injections was significantly potentiated (31 +/- 6 and 35 +/- 4%, respectively). These data suggest that exercise training caused significant changes in the coronary vascular response to alpha-receptor stimulation so that an alteration in the neural control of the coronary circulation occurred.
登录
查看更多内容
DOI:
10.1042/bj2320403
发表时间:
1985-12
期刊:
The Biochemical journal
影响因子:
--
作者:
S. Zeisel;K. daCosta;James G. FOXt
通讯作者:
S. Zeisel;K. daCosta;James G. FOXt
影响因子:
4.7
作者:
Zeisel,SH;DaCosta,KA;Edrise,BM;Fox,JG
通讯作者:
Fox,JG
DOI:
--
发表时间:
1976
期刊:
Food and Cosmetics Toxicology
影响因子:
--
作者:
S. Tannenbaum;M. Weisman;D. Fett
通讯作者:
D. Fett
DOI:
10.1016/s0015-6264(73)80369-4
发表时间:
1973
期刊:
Food and cosmetics toxicology
影响因子:
--
作者:
R. Lane;M. E. Bailey
通讯作者:
M. E. Bailey
影响因子:
1.8
作者:
J. L. Bruning;B. Kintz
通讯作者:
B. Kintz