Colchicine blocks the action of parathyroid hormone but not nicotinamide on renal phosphate transport.
Colchicine blocks the action of parathyroid hormone but not nicotinamide on renal phosphate transport.
复制标题
秋水仙碱阻断甲状旁腺激素但不阻断烟酰胺对肾脏磷酸盐转运的作用。
DOI：
10.1016/0005-2736(87)90454-8
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Kempson,SA
中科院分区：
文献类型：
--
作者：
Bacon,RA;Wu,KI;Ying,AL;Kempson,SA
Nicotinamide, like parathyroid hormone, is a rapidly acting specific inhibitor of Na+-dependent transport of phosphate (Pi) across the brush-border membrane of the proximal tubule of the mammalian kidney. Pretreatment of rats with colchicine (0.7 mg/kg body weight) for 1 h led to a significantly diminished phosphaturic response to parathyroid hormone (synthetic 1–34 fragment, 4 μ/kg). In contrast, the same dose of colchicine had no effect on the renal response to nicotinamide (1.0 g/kg), measured both as the change in urinary Piexcretion and as Na+-dependent Piuptake by isolated brush-border membrane vesicles. These data suggest indirectly that the intracellular mechanism that mediates the inhibitory effects of nicotinamide on renal Pitransport does not require intact microtubules.
