DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics.
DAPAR & ProStaR: software to perform statistical analyses in quantitative discovery proteomics.
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DOI：
10.1093/bioinformatics/btw580
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Burger T
中科院分区：
文献类型：
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作者：
Wieczorek S;Combes F;Lazar C;Giai Gianetto Q;Gatto L;Dorffer A;Hesse AM;Couté Y;Ferro M;Bruley C;Burger T
DAPAR和ProStaR是对基于XIC的无标记定量发现蛋白质组学实验进行统计分析的软件工具。DAPAR包含过滤、标准化、插补缺失值、聚合肽强度、执行零假设显著性检验以及选择具有相应错误发现率的最可能差异丰度蛋白质的程序。ProStaR是一个图形用户界面，允许通过Web浏览器友好地访问DAPAR功能。DAPAR和ProStaR是用R语言实现的，可在Bioconductor项目网站上查阅（http：//www.bioconductor.org/）。一个完整的教程和一个玩具数据集是伴随着包。
DAPAR and ProStaR are software tools to perform the statistical analysis of label-free XIC-based quantitative discovery proteomics experiments. DAPAR contains procedures to filter, normalize, impute missing value, aggregate peptide intensities, perform null hypothesis significance tests and select the most likely differentially abundant proteins with a corresponding false discovery rate. ProStaR is a graphical user interface that allows friendly access to the DAPAR functionalities through a web browser. DAPAR and ProStaR are implemented in the R language and are available on the website of the Bioconductor project (http://www.bioconductor.org/). A complete tutorial and a toy dataset are accompanying the packages.