Network synchrony in the nucleus accumbens in vivo
Network synchrony in the nucleus accumbens in vivo
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DOI：
10.1523/jneurosci.21-12-04498.2001
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发表时间：
2001-06-15
影响因子：
5.3
通讯作者：
O'Donnell, P
中科院分区：
文献类型：
--
作者：
Goto, Y;O'Donnell, P
延髓核神经元表现出非常负的静息膜电位和周期性平台去极化之间的膜电位波动。由于动作电位放电只发生在去极化状态，状态之间的转换控制是很重要的信息处理在这个区域内，与影响相关的行为。有人提出，丘脑核中活跃神经元的集合可能是基于同时去极化进入UP状态的细胞群。在这项研究中，在体内的细胞内记录从小脑神经元进行了同时与当地的场电位记录，以检查是否可以表现出同步的神经元的群体中的膜电位状态的小脑核。这些同时记录表明，局部场电位的变化同步发生的过渡到UP状态。此外，诱发长时间高原去极化的操作也诱发了相似持续时间的场电位。这种信号可能是由于神经元群体中同时发生的膜电位变化而发生的。结合我们以前的研究结果，这些结果表明，突触输入可以同步的突触输入海马神经核的膜电位状态。
Nucleus accumbens neurons show membrane potential fluctuations between a very negative resting membrane potential and periodical plateau depolarizations. Because action potential firing occurs only during the depolarized state, the control of transitions between states is important for information processing within this region, with an impact on accumbens-related behaviors. It has been proposed that ensembles of active neurons in the nucleus accumbens could be based on a population of cells depolarizing simultaneously into the UP state. In this study, in vivo intracellular recordings from accumbens neurons were performed simultaneously with local field potential recordings to examine whether the nucleus accumbens can exhibit synchronization of membrane potential states in a population of neurons. These simultaneous recordings indicated that local field potential shifts occurred synchronously with transitions to the UP state. Furthermore, manipulations that evoked prolonged plateau depolarizations also evoked field potentials of similar duration. Such signals likely occurred because of simultaneous membrane potential changes in a population of neurons. Together with our previous studies, these results suggest that membrane potential states in the nucleus accumbens can be synchronized by synaptic inputs from the hippocampus.