Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence‐attenuated SHIV 89.6
Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence‐attenuated SHIV 89.6
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DOI：
10.1111/j.1600-0684.2005.00125.x
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发表时间：
2005-10
影响因子：
0.7
通讯作者：
C. Miller;K. Abel
中科院分区：
文献类型：
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作者：
C. Miller;K. Abel
摘要：尽管人类免疫缺陷病毒1型（HIV）减毒活疫苗可能永远不会在临床上使用，但这些疫苗在猴免疫缺陷病毒（SIV）/恒河猴模型中提供了最持久的静脉（IV）攻击保护。毒性减毒猴-人免疫缺陷病毒（SHIV）89.6的全身感染可提供针对阴道SIV攻击的保护。本文综述了与SHIV 89.6/SIVmac 239模型中的先天性和适应性免疫反应以及炎症与保护作用相关的研究结果。通过一种尚未明确的机制，大多数接种减毒活SHIV 89.6的猴产生了有效的抗病毒CD 8 + T细胞应答，同时避免了在未保护和未接种猴的淋巴组织中发现的自毁性炎症循环。
Abstract: Although live‐attenuated human immunodeficiency virus‐1 (HIV) vaccines may never be used clinically, these vaccines have provided the most durable protection from intravenous (IV) challenge in the simian immunodeficiency virus (SIV)/rhesus macaque model. Systemic infection with virulence attenuated‐simian–human immunodeficiency virus (SHIV) 89.6 provides protection against vaginal SIV challenge. This paper reviews the findings related to the innate and adaptive immune responses and the role of inflammation associated with protection in the SHIV 89.6/SIVmac239 model. By an as yet undefined mechanism, most monkeys vaccinated with live‐attenuated SHIV 89.6 mounted effective anti‐viral CD8+ T cell responses while avoiding the self‐destructive inflammatory cycle found in the lymphoid tissues of unprotected and unvaccinated monkeys.