Prognostic value of tumor infiltrating NK cells and macrophages in stage II+III esophageal cancer patients.
Prognostic value of tumor infiltrating NK cells and macrophages in stage II+III esophageal cancer patients.
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肿瘤浸润NK细胞和巨噬细胞在II III期食管癌患者中的预后价值
DOI：
10.18632/oncotarget.12484
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发表时间：
2016-11-15
期刊：
影响因子：
--
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Xu B;Chen L;Li J;Zheng X;Shi L;Wu C;Jiang J
对肿瘤微环境免疫生物学的详细了解已经转化为治疗人类癌症的新方法。除了免疫细胞介导适应性免疫应答的作用外，固有免疫系统的肿瘤浸润成分，包括中性粒细胞、肥大细胞、NK细胞和巨噬细胞，也在抗肿瘤免疫中发挥重要作用。在本研究中，我们回顾性分析了II+III期食管癌患者组织中肿瘤浸润NK细胞和巨噬细胞密度的预后价值。我们的研究结果表明，浸润NK细胞在肿瘤基质中的密度与淋巴结状态显著相关。此外，肿瘤巢内浸润的NK细胞密度、肿瘤巢内浸润的巨噬细胞密度以及肿瘤间质中浸润的巨噬细胞密度与患者术后预后有显著相关性。此外，肿瘤巢与间质浸润NK细胞联合，或肿瘤巢与间质浸润巨噬细胞联合，也可作为预测II+III期食管癌患者生存的重要预后工具。
The detailed understanding of the immunobiology of tumor microenvironment has recently translated into new therapeutic approach against human cancers. Besides the role of immune cells mediating adaptive immune responses, the tumor infiltrating components of the innate immune system including, neutrophils, mast cells, NK cells, and macrophages, also role importantly in anti-tumor immunity. In our present study, we retrospectively analyzed the prognostic value of the densities of tumor infiltrating NK cells and macrophages in esophageal cancer tissues derived from stage II+III patients. Our results showed that the density of the infiltrating NK cells in tumor stroma was significantly associated with nodal status. In addition, the densities of the infiltrating NK cells in tumor nest, and the infiltrating macrophages in tumor nest as well as in tumor stroma, were significantly associated with patients' postoperative prognoses. Furthermore, the combination of infiltrating NK cells in tumor nest and stroma, or the combination of infiltrating macrophages in tumor nest and stroma, could also be used as important prognostic tool in predicting the survival of the stage II+III esophageal cancer patients.