BORDETELLA-PERTUSSIS RESPIRATORY-TRACT INFECTION IN THE MOUSE - PATHOPHYSIOLOGICAL RESPONSES
BORDETELLA-PERTUSSIS RESPIRATORY-TRACT INFECTION IN THE MOUSE - PATHOPHYSIOLOGICAL RESPONSES
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DOI：
10.1093/infdis/142.1.56
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
WARDLAW, AC
中科院分区：
文献类型：
--
作者：
PITTMAN, M;FURMAN, BL;WARDLAW, AC
生活B的影响。研究了不同剂量的百日咳菌液对小鼠鼻内感染的病理生理反应的诱导和持续时间的影响。致死性感染的小鼠表现为体重减轻、脾脏萎缩、明显的体温过低和低血糖，以及白细胞和血清免疫反应性胰岛素水平的高度升高。亚致死性感染的小鼠表现出正常的体重增加，几乎正常的温度，脾脏肿大，不太明显的低血糖症，较低但显着升高的水平的白细胞和血清免疫反应性胰岛素，组胺致敏。每种反应的强度与肺部感染的程度有关。低体温与白细胞增多高度相关。血清免疫反应性胰岛素浓度与白细胞升高密切相关，而与血糖水平无关。小鼠的品系和年龄显著影响反应的程度和持续时间。结果表明，鼻内感染的小鼠可能为百日咳的研究提供一个有用的模型。
The influence of living B. pertussis on the induction and duration of pathophysiological reactions in mice infected intranasally with graded doses of culture was studied. Lethally infected mice showed loss of body weight, spleen atrophy, pronounced hypothermia and hypoglycemia, and highly elevated levels of leukocytes and serum immunoreactive insulin. Sublethally infected mice showed normal weight gain, practically normal temperature, spleen enlargement, lesser pronounced hypoglycemia, lower but significantly elevated levels of leukocytes and serum immunoreactive insulin, and histamine sensitization. Intensity of each reaction was related to the degree of lung infectivity. Hypothermia and leukocytosis were highly correlated. Concentration of serum immunoreactive insulin was closely related to the level of leukocytosis but not to the level of glucose. The strain and age of mice significantly affected the degree and duration of the reactions. The results suggest that the intranasally infected mouse may provide a useful model for investigations on whooping cough.