Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery:: A comparative study
Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery:: A comparative study
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DOI：
10.1016/j.colsurfb.2007.09.018
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发表时间：
2008-03-15
影响因子：
5.8
通讯作者：
Delgado, Angel V.
中科院分区：
文献类型：
--
作者：
Arias, Jose L.;Adolfina Ruiz, M.;Delgado, Angel V.
由于新的治疗途径对癌症治疗的根本重要性，许多治疗方法。以胶体颗粒为载体的化疗药物输送系统已经被设计出来。目标始终是只在所需的作用部位提供适当剂量的抗肿瘤药物，从而减少不想要的副作用。本工作研究的体系是生物可降解聚合物聚(氰基丙烯酸乙酯)、聚(氰基丙烯酸丁酯)、聚(氰基丙烯酸己酯)和聚(氰基丙烯酸辛酯)的纳米球，它们都适合作为5-氟尿嘧啶的载体，5-氟尿嘧啶是一种广泛研究的用于治疗实体肿瘤的药物。分析了两种载药方法：一种是基于粒子形成过程中的药物添加，通过阴离子乳液/聚合过程，以及随后的药物在聚合物网络中的捕获。第二种方法是基于已经形成的纳米颗粒在药物溶液中孵育后的表面吸附。详细研究了聚合物微粒对该药物的吸附能力。影响药物进入聚合物网络的主要因素是单体类型、pH和药物浓度。5-氟尿嘧啶的释放动力学受释放介质的pH、药物掺入类型和聚合物类型的控制。(C)2007 Elsevier B.V.保留所有权利。
Because of the fundamental importance of new therapeutic routes for cancer treatment, a number of. systems based on colloidal particles as vehicles for the delivery of chemotherapeutic agents have been devised. The target is always to provide the proper dose of the antitumour agent only at the desired locus of action, thus reducing the unwanted side effects. The systems studied in this work are nanospheres of the biodegradable polymers poly(ethyl-2-cyanoacrylate), poly(butylcyanoacrylate), poly(hexyl cyanoacrylate) and poly(octylcyanoacrylate), all suitable for parenteral administration, as vehicles for 5-fluorouracil, a well studied drug used for the treatment of solid tumours. Two loading methods have been analyzed: the first one is based on drug addition during the process of generation of the particles, by an anionic emulsion/polymerization procedure, and the subsequent drug trapping in the polymeric network. The second method is based on surface adsorption in already formed nanoparticles, after incubation in the drug solution. A detailed investigation of the capabilities of the polymer particles to toad this drug is described. The main factors determining the drug incorporation to the polymer network were the type of monomer, the pH and the drug concentration. The release kinetics of 5-fluorouracil is found to be controlled by the pH of the release medium, the type of drug incorporation and the type of polymer. (c) 2007 Elsevier B.V. All rights reserved.